Before I share briefly my experience with PS128 I want to emphasize that this probiotic may not have the same effect on everyone, as we know we are all different.
For four years I have been looking for something to help me with my symptoms. Many of the supplements I use have not given any specific relief until the probiotic Lactiplantibacillus (Lactobacillus) Plantarum PS128, which I felt the other day.
It is not a placebo to immediately dismiss this dilemma because I know this matter very well. My brief experience with the PS128 is 7 days. I know it's too early for some conclusions about its effectiveness, but I couldn't bear to share this news with you. I won’t write much about probiotics. I will put the website so that you can read it for yourself.
I'm sorry to hear that. Like I said we are all different and the way we developed this unhealthiness. How long has mom had Pd? And what are her main symptoms?
She has PD since 11 years now. Gave it to her( 60 billion dose/day) almost a year and a half back and did not make a difference. It was from Solace Probiotic, same strain - PS128. (see link below).
She has almost all the typical symptoms associated with PD - constipation - now manageable, balance and gait issues, freezing before walking, anxiety, confusion, fatigue and tremors. But she sleeps well, eats well, can walk for a furlong without stopping if and when she is in the mood - (which is rare).
Basically I emailed Benedbiomed and asked them for their supplier in Asia.
the website is wellbeingsg.com
Product is called ACTIV health multibiotics containing PS128 +K21
My husband takes 2 sachets according to the clinical trial.
The best thing is to email Benedbiomed, and ask them where you can purchase it. You want the same product. They can name it whatever they like. It is a life changer.
Yes this is the one. Wow S$10 is a steal. It works out to £5 a box excluding shipping. Is the expiry Dec 2021?Everyone who wants to try order this now. It’s a giveaway. It wd be good to order the maximum amount that the £40 shipping cost can allow you.
Thank you for posting the image. I did not know how to do it.
Did it help your husband with Tremors and Dystonia as these are the major symptoms I suffer from predominantly all left sided Very painful Dystonia with my toes, fingers and hand cramping and curling in on themselves and severe tremors in my foot and hand 🙏
If you refer to delboy381’s post he said it helped with tremors amongst other things.My husband does not have tremors. He had akinesia-slowness of movt- and balance was a really big thing and he was prone to tripping and falling. So with PS128 his balance was normalised, no more akinesia.
Unlike delboy who cd perceive the difference when taking PS 128, my husband cannot give any feedback. As caregiver I see the improvements.
His driving also improved tremendously, anxiety, sleep all improved as did nocturia
So happy for you and your husband I hope it helps me with my Tremors and Dystonia as they are really awful at the moment 😞😞One can only try and 😯prey and hope for the best 🙏
Yes, but I'm in the US and when I go to their website to buy it, there's no shipping option for the US. I suppose it has to do with politics, the pandemic, or the broken supply chain, but that's all beyond my control. Maybe I'll have to row my little boat there!
Jeanie, I sure wish the L-Plantarum from Swanson was the same as the PS128 probiotic because I have been having a difficult time finding out where I can purchase it. Evidently it is made somewhere in Asia and not available in the U.S. But there are many strains of L-Plantarum. Here is some info I came across:
Lactobacillus plantarum has been isolated from a variety of hosts such as plants, the human gastrointestinal tract, animals such as poultry and insects, as well as a variety of foods such as meat, fish, vegetables, olives and raw or fermented dairy products (2,4).
Lactobacillus plantarum has been used as a starter culture in the fermentation of many foods such as (5,6):
• Yogurt with live and active cultures
• Raw, unpasteurized sauerkraut
• Pickles brined in water and sea salt
• Raw, aged cheese such as Swiss, provolone, Gouda, Cheddar, Edam, Gruyére, and cottage cheese
• Traditionally baked sourdough bread
• Kefir
• Tempeh, or fermented soybeans
There are a diverse array of lactobacillus plantarum strains the history and evolutionary lineage of which is not clear.
Scientist found the PS128 strain in fermented Chinese Mustard Greens. Evidently this is a common culture condiment in Asia . If anyone knows how we can purchase this probiotic (psychobiotic) in the U.S. please let me know. I would be forever grateful.
Hi. My husband has tried it now on two separate occasions with no improvement. In fact it affected him adversely but there could have been other factors. He has had PD 28 years though and had DBS so nothing is straight forward.
Jeanine if your husband used Swanson's brand it is not the same and therefore cannot have the same affect that has been mentioned here. If it contained PS128 in any significant amount it would specify it on the bottle.
What my reply was trying to explain in that there are a diverse array of lactobacillus plantarum strains and they each do different things in the body. The PS128 strain has been patented and is the strain that has been found to help Parkinson's.
I ordered some today at Solace Probiotics for my husband and will let you know if it works for him. It is expensive but they offer 15% off if you sign up for a subscription which you can change or cancel at any time. They also ship free in the U.S. Hope that helps. Wishing you the best.
Yeh I know it’s not the same products as Delboys I just put it on for info and for the price of it…It actually says it’s got the same amount of PS128 in it..Sorry it hasn’t worked for you but like Delboy says everybody’s different and certain things work for one person but not another..Unfortunately that’s the problem with this Godforsaken disease
See earlier post from “Millbrook” for the one her husband uses with great success and the company she gets it from They’re selling a pack for $10 at the moment due to going out of date soon..I’ve just ordered 2 boxes and they ship all over the world..I’m in the UK
Solace is very expensive when compared to wellbeingsg.com. I have been wanting to buy it but couldn’t get past the price on solace. I just bought 6 months worth ( 12 boxes) from the wellbeingsg.com for about the same price as 3 boxes from solace. I’m hoping it is worth it!
Curious thing re the French product - looking at the website for Bened, the company developing PS128, they have a world map showing location of manufacturing facilities, and also "Bened product markets" - France is not included in either. Hmm. Also I found an article from a couple of years ago with the headline "EU firm Beopanax selected as exclusive psychobiotic product distributor". But maybe this is out of date?!
So, struggling to find out how to get it to the UK now, without going with the French "Neurobiotique". I think I'll send a quick message to Bened asking on both issues.
I left a message for them on their site re both questions above, and the advisability of international postage given requirement for refrigeration - will post here their response when they get back to me.
"..we provided PS128 to Synergia for their product in the past. Currently, we are supplying the strain in the EU to Neuraxpharm (for product Neuraxbiotic Spectrum, sold in Spain, Portugal, Germany, Poland, Czech Republic, Slovakia, Austria, Hungary, Italy) and Beopanax (for product Second Brain, sold in Serbia, Kosovo, Bosnia, Montenegro, Macedonia, Croatia, Slovenia, and Albania).
Regarding shipping and efficacy, you're right that lack of temperature control can negatively affect a probiotic's potency. The PS128 strain should always be refrigerated when possible. We know that is not always practical during shipping, so each of the products listed above include enough overage (extra PS128 above the amount guaranteed for each dose) for at least that amount left at their expiration date - even considering some shipping time at room temperature. Especially now that outside temperatures are cooler, the CFU count should not be decreased by much before the order reaches you.
Unfortunately, there is not currently a distributor selling a product with PS128 in the UK. In the meantime, I can recommend a few different PS128-containing products:"
- They go on to recommend Solace (US) and Activhealth (Singapore) in addition to the above. I've now bought from the latter, with the special offer, close to use by date sachets. Also asking Bened to check that freezing is unwise (probably) and what the normal shelf life is, so I can see how quickly it degrades.
Another reply from Bened:"Under normal refrigeration, PS128's shelf life is at least 2 years. Freezing the product is just fine. Feel free to store them that way if you'd like to keep them even longer."
Nice! So the almost expired products many here are buying can be chucked in the freezer to last for longer.
Looks interesting, and the price is good (had to look hard to see it is 30 sachets!), unfortunately they dont give a breakdown for the number of PS128 cells vs the two other cultures they have in the sachets. Although PS128 is listed first on the ingredients, so I guess the minimum is 1/3rd. Give the low price I guess just take more :).
This is widely available in mainland Europe, but waiting to find out if there’s a UK distributor.As I understand it is, Neuraxpharm are the European Licence holder
I'm glad to receive your email. We are currently working with a distributor in India, and the product is nearing the registration stage. However, that process is likely to take several months before the product is available for purchase from India. I will be sure to let you know when that happens.
In the meantime, Activhealth in Singapore (Multibiotics | Activhealth | Healthy Mind, Healthy Body) and Solace in the US (SOLACE – Solace Probiotic) may be able to ship internationally. Please contact them directly for specific product information or to purchase.
Curious why you think the Active is recommended for PD, did you ask one of the companies for advice? I've sent a quick message to see if my order can be amended to some of both, so I can try each on my Mum when they arrive (has MSA)
Yes I spoke to them and when I mentioned PD they said ACTIVE was the one I should order. I had initially ordered MIND but changed to ACTIVE after speaking to them.
So my husband has been on it since june. It has been about 4.5 months
I did speak to them about K21 and what it was supposed to do. She mentioned reducing inflammation and lipids. I was too happy that I could get the product, made in Taiwan right here. And since she said her PD clients took ACTIVE I ordered it. They also have other probiotics for autism , depression etc
PB look at OAFC ‘s post on the PS 128 that my husband is taking. It’s on special about £5 a box. You have to pay for shipping but you can order the max amount that yr shipping costs allows. The website is wellbeingsg.com
Last week I received my second order of Solace (3 boxes) which is very expensive. Thanks to you and OAFC, I will start ordering the one you have been using on your husband. I bookmarked the site. Thanks!
I think that the product can still be consumed one or two months after expiry date. It’s essentially powder form and as long as it is stored properly should be fine.
That’s just my opinion.
It’s amazing the delboy381 only takes 1 sachet and has got such good results. The clinical trial used 2 sachets at bedtime.
I glad to hear that. I don’t want to claim anything about this probiotic, but so far for the first time I feel like something from the supplements is helping me. It boosted my self-confidence. My opinion is that the end of this unhealthiness is getting closer. One part of Michael's interview I recently read:
With the Foundation, which has raised over $1 billion to date for Parkinson's research, "we are loading up all the cannons we can and pointing them at the target," Fox told PEOPLE earlier this week. "One of them will fire and it will happen. The disease is a problem that will be there until you solve it. But we're hopeful."
I wrote a post on PS 128 in June 2021. Within 2 weeks there was 180 degree turnaround affecting balance, stiffness, slowness, driving. Everything was normalised. It was a miracle. My husband takes 2 sachets -60 billion- at bedtime.
He took the probiotic at the same time as doing the coronet duo 2x a day so now we are committed to both.
I am so happy for you that PS 128 accomplished as much as it did for us.
My husband has been taking it since June and continues to take it daily and the improvements have been sustained. You can click on my icon and read my post on PS 128. Like you I was so excited and happy about the improvements I could not wait to share with my friends here on HU so that they too could experience the same benefits.
I'm glad to hear that. Believe me, I felt the effect after the second day. I use one sachet and take it before lunch, mixing it with water for half an hour. Like I told Art, it boosted my confidence. Time will tell. I wish you all the best. Oh, can you put where you buy ps128?
I hope shipping from Singapore is done in a way that the product isn't damaged in shipment. Many but not all probiotics are very sensitive to temperature.
According to the supplier the product is not affected by temperature unless it is very hot but best to store it in cool and dry place once you receive it.
That seems surprising. All lactobacillus are sensitive to temperature and deteriorate quite quickly. You can probably test viability by making a yoghurt from a sachet. Don't worry what it tastes like, as long as it ferments into yoghurt
Personally I store mine in the fridge though I was told it was not necessary as long as it was a cool place. Heat is more of a problem here. I will try making yoghurt with it and let you know.
I made a yoghurt with one sachet of PS128+K21. After some of you mentioned temperature concerns ( nowhere is hotter than being on the equator) I did it to placate my own fears that all the live probiotic were dead.
So happy to report yoghurt taste really nice and pleasant- not sour
Have you actually received your order? I placed an order from the Singapore site 12 days ago and just received this message "... the parcel has just been rejected by the US customs due to some unforeseen circumstances." 😔
I received my first order. I placed a second order and have not received it or a message like yours. I messaged them through their website, waiting for a reply.
I placed an order over a month ago & it was also refused at customs, then returned to Singapore. Because of these refusals they are no longer shipping to the US.
Hi, were you able to get it shipped to USA? I ordered the Activhealth – Multibiotics thru wellbeingsg.com from Singapore about 3 weeks back. It's currently showing that the shipping package has arrived in US but held at the Customs.
Does anyone has an idea how to get it released from US Customs?
Hello-Unfortunately, US Customs returned it back to WellBeing in Singapore. I was given a prompt full refund and WellBeing said they were going to change their site to not allow US buyers to purchase it, because of the many orders being returned by customs.
Oh ok, sorry to hear that. Looks like it's going to be the same experience for me as well and will prolly be returned by the US customs. Fingers crossed though!
Yes, I realize. I just wondered why that one was preferred. I read more this morning and did choose that one. After such connection trouble last night I tried again this morning and finally was able to complete order. There was no 1 for 1 that I could find but I was able to get a good deal, I thought. Just now hoping for survival in the shipment. Thank you for your contributions to this group, Millbrook.
Hi! Was wondering if your husband is still using this and if it continues to have positive effects? I haven't seen any recent posts from you and am considering ordering.
Hi. Sorry just saw your message. Yes, he is still taking 2 sachets before bedtime every night. It is something that he will continue taking for life. It seems that 70% of dopamine is produced in the gut . This probiotic is God sent.
I notice that with the French sourced version, they suggest storage at between 4 and 7 degrees, preferably in the refrigerator. Seems precise and I wonder if this applies to other versions? Would international shipping affect the efficacy, as storage temperature would be out of control?
Yes definitely the conditions during shipping Will affect the efficiency. I had contacted the main manufacturer a few months back and his reply was as under"I’m glad to receive your email. Currently, we do not have a distributor that covers your country. PS128 is a delicate probiotic that is best kept refrigerated and shipped via cold chain, and logistically, that is quite difficult in your country. Our Singapore distributor, Multibiotics | Activhealth | Healthy Mind, Healthy Body, may be an option. Please contact them directly and see.
If there is anything else I can help with, please let me know.
Sorry, I have a different experience. I take PS128 already 2 months - 60 billions daily. There are no improvement of none of my symptoms. My PD was diagnosed two years ago. This is NeuraBiotic Spectrum produced by Bened Biomedical Co.Ltd in Italy.
I have emphasized that we are not all the same and that it may not have the same effect in another, similar to B1. It is not my intention to give false hope to anyone.
We are in a position to look for what will make our life easier and better. All the best.
Sorry to hear that Robert. Perhaps you may want to try the coronet Duo that other members are using as well. My husband used coronet duo and PS128 simultaneously. I was inclined to think that the change was due to PS 128 because red light takes time to be effective.
We are not promoting any product and have nothing to gain from it other than helping others get better.
In the clinical trial that ran for 12 weeks 70% of participants experienced improvements and 20 % of the 70% experienced great improvements.
It is worth trying for everyone. It does not cost an arm and a leg at the clearance price and it could very well change your life.
It was life changing for me. Previously I could not leave my husband alone for fear of falls. Now his balance is normal and he can function independently. He is more alert and functions normally in everything. The slowness is gone. It’s a miracle 😭
It could be beneficial.I don't have PD I have Parkinsonisms and I've been taking it for 6 weeks with a lot of other supplements. Had some minor tremor improvements hard to say because of what. But I have stopped now because recently I am experiencing some dizziness (don't know the reason yet) and I'm on regular probiotics.
If you want to try PS 128 now would be a good time as they are clearing stocks that are due to expire Dec 2021. This is the one that my husband is taking. It works out to about £5 for a box of 30 sachets excluding shipping. Best to order maximum amount that the standard shipping allows.
The website is wellbeingsg.com
You would need 2 boxes a month as the clinical trial used 60 billion at bedtime for 12 weeks.
For all I know, the very inexpensive Swanson L. Plantarum supplement might be partially comprised of the PS 128 strain. In fact, it might even be entirely comprised of PS 128. The label simply does not specify which substrain of L. Plantarum is in the bottle.
Yes, I saw this too. So, you'd take 12 capsules a day?
Cost is about $12/day or about $360/mo!
What if I bought one month's supply of Solace then used some of that to ferment my own PS128? (Instructions on how to make your own probiotics are easily found on the internet.) According to Solace's website, they use fermented mustard greens. The only problem is dosing, but is that really a problem? After all, we're talking about swallowing fermented food (that is quite safe; fermented foods have been around a long time and are generally health-promoting). These fermented foods already have, by definition, bacteria that caused the fermentation. If I'm careful and introduce PS128 into the process I should be able to consume at least a small amount of the fermented mustard greens without any problems. If I get too much of it, my gut might make even more dopamine than somebody getting "just" 60bln CFUs. That wouldn't be terrible. Am I wrong?
It will be interesting to see a longer term report. "Next day" improvements are usually placebo effect, but not always.
"The trials" are far from conclusive (human PD trials - not immodium induced mouse constipation trials)
NCT04722211 - a proper trial, listed Jan 21, 120 participant placebo controlled , still recruiting, due to report end next year
PMC8277995 - open label, 25 participant 12 week duration 2021. Interesting, but needs a trial like NCT04722211 to corroborate
NCT04389762 open label 120 participant 12 week duration COMPLETED June 2020 - no results posted. No results posted 15 months later usually = "didn't work"
NCT03566589 2018 trial - no results posted
The trials are all of PS128 - not the cocktail with K21. So 60 billion cfu of a reputable sourced PS128 - like Synergia Neurobiotique, if kept cool in transit and storage, should be equivalent to the trial.
Forum feedback on this thread seems to be pretty evenly split between "didn't work for me" and "great results"
As I said at the start, it will be interesting to see the results 6 months out
I understand that a licence has been granted in Europe to Neuraxpharm, to distribute PS128 . The Neurorax Biotic Spectrum product looks widely available in continental Europe, but not UK. I have emailed the company to see if there is a UK supplier.
I used to make wines with a group of friends and we started by using prepacked yeast variety's . being slow learners it took about 15 years to smarten up and use a yeast that mother nature developed rather than just any old 'YEAST' and we started to have superbly flavour and body, etc.
Think of that statement about bunch of grapes down in the far corner of the Vinyard that is harvested yearly and has superb flavour and body. far better than the rest of the variety adjacent.
Now, what is one of the factors that is missing from this discussion of a very finely (?rare) refined yeast? (PS218)
If you give up here is the answer: There has been NO discussion of the foods or style of meals/foods ie Vegan, Meat-a-terian, etc.
The inclusion of that information would help others reading "It worked for me" if there is a reasonable chance of success.
Hi, I use one sachet half an hour before lunch. Honestly I have stomach pain sometimes and I guess that’s normal because there’s a little war going on in the gut flora. A member Millbrook her husband used in the way described in the study, at bed time. I said time will tell how effective this probiotic is.
I just made a batch of yoghurt from 1 sachet of PS128 +K21. So they are alive! Maybe you may want to try. Only thing is you will not know how many billion in it and how much to consume to get 60 billion dose
I purchased some from Solace in the summer. The first shipment arrived hot (literally hot to touch) and I asked for a replacement. The next batch was a bit warm, but not as bad.
Customer Service said -
"In regards to your concern about Solace being exposed to heat, there was a study conducted examining this very question. When tested at 77 degrees Fahrenheit (5 degrees above room temperature) for 30 days, 75% of the probiotics survived. When tested at 99 degrees Fahrenheit, for 15 days 50% of the probiotics survived."
I tried one and got a definite effect a few hours later - a flare up of lower back and urogenital pain. Same as what happens if I take Lion's Mane.
So it isn't for me, but FWIW my experience was that even after getting hot it did appear to be active and it did something. I can't speak to PD symptoms since I don't have PD.
The strain was isolated and patented by Professor Tsai Ying-Chieh[13] (National Yang-Ming University) and sold as a supplement ingredient by the company he founded, Bened Biomedical.[14]
In Europe, CNS pharmaceutical company Neuraxpharm, markets a product for autism containing PS128.[15] Synergia sells in the probiotic in France.
Solace and Thryve are brands containing PS128 in North America.
In Malaysia, Nuvanta sells a PS128 product.[16]
In 2020, Blackmores, an Australian health supplements company, announced plans to develop a PS128 product for the Australia/New Zealand market.[17]
My husband is still taking 2 sachets a day at bedtime and will continue to do so. The improvements remain. He does not have issues with slowness, driving, balance he previously had.
He has not been diagnosed. He lost his sense of smell about 8-10 years ago together with gut problems , active dreams which were even earlier. He also had nocturia waking 6-8 times a night. Three years ago, started having frozen facial muscles, choking on saliva, Poor lane discipline when driving and slowness. Started vitamin B1 and it improved. Balance was worse this year and we started coronet duo and PS 128 and it has been very good especially his balance and driving. Everything is normal.A visit to neurologist last year for vertigo confirmed that he was slower on one side. His advice was PD has slow progression and not to worry about it and there are meds to help. He said he could not definitively say he had PD or he did not have PD.
Essentially saying we will deal with it as it goes.
Time for another PS128 update? I'm not sure why this showed up in my feed because I can't see any recent entries. However, it sounds like a few people may have began taking this about 6 months ago. Does anyone have anything to report, good or bad?
Since this stuff is so expensive in the USA, has anyone tried to make yogurt with it? Dr William Davis's book Super Gut has instructions. With yogurt making you would only need 1 box for $99 and then use a couple of Tbs of made yogurt, to make a new batch.
Hi All, as you know by now, Bened LIfe bought Solace and has a US patent on lactobacillus plantarum ps128 which they call Neuralli. They are now charging $164 a bottle or $115.50 a bottle if you buy three months worth.
If you're looking to save money and you look elsewhere out of the US, either the product is out of stock or shipping costs make it even more expensive than Neuralli. I have emails out to a pharmacy in Spain where I can't even do a Euros to $ conversion because of the crazy way they've stated the price, but this aside, I can't find any less expensive source. As if we didn't all deal with high enough costs already between supplements and drugs, right?
Does anyone know of a reasonably priced source for lactobacillus plantarum ps128 where shipping to the US doesn't break the bank...or does such a source not exist and we're stuck with the cost of Neuralli here in the US?
This pilot study says you can take it with any PD drugs. The Add-On Effect of Lactobacillus plantarum PS128 in Patients With Parkinson's Disease: A Pilot Studyfrontiersin.org/articles/10...
Ok, so the person I care for who has PD bought a 3 mo. supply of Neuralli because they want to emulate the pilot study on Lactobacillus plantarum PS128 which went for 3mo. So I'll be back on this thread sometime after the first of the year to let you all know our results.
I think the scientific orthodoxy is that dopamine made in the gut can't cross the blood brain barrier, and that would include can't dodge it via the vagus nerve, and that it is a cause of side-effects . Drugs like Carbidopa are used to stop dopamine being metabolised outside the brain.
Is there any good evidence for this belief of some people?
My wife recently finished her 6th bottle (6th month) of Neuralli. I was going to come back after three months and post about our experience, but wanted to extend our trial period to provide more thorough feedback. So now it’s been 6 months and, as promised, I’m back to share our results.
A few details about my wife and I first:
1. My wife was diagnosed with PD 12years ago. I am her husband and caretaker.
2. Her symptoms from the beginning have been her right side is weaker than her left and she sometimes catches her right foot while walking as a result. She very occasionally has shaking in her right leg, but typically this only happens when her medication wears off. She really has no dyskinesia or dystonia to speak of so we’ve been lucky in this regard. A few years ago she was diagnosed with SIBO and was given two courses of a powerful antibiotic called Xifaxan which got rid of the SIBO, but she still suffered from IBS symptoms like constipation, gas and bloating afterwards.
3. Her main problem now is her response to the levadopa/carbidopa medication. She has slowly required more pills more often during the day. She was taking about eight 25/100 pills between 7:00AM and 10:00PM and 2 Sinemet CRs at night before bed. A year ago we added amantadine 100mg (1/2 pill, 2x daily)
4. Her symptoms present as fatigue, slowness, stiffness, etc. if her medication dosage is too low and as agitation, overstimulation and unstable walking if it’s too high. This is referred to typically as LID (Levadopa Induced Dyskinesia), but my wife doesn’t really have much noticeable dyskinesia.
5. Other than levodopa/carbidopa 25/100, amantadine 100mg, and a few basic supplements, my wife doesn’t take anything else for her PD, with one notable exception which I’ll discuss next.
L. plantarum PS128:
“Lactobacillus plantarum PS128 (PS128) is a specific probiotic, known as a psychobiotic, which has been demonstrated to alleviate motor deficits and inhibit neurodegenerative processes in Parkinson's disease (PD)-model mice. We hypothesize that it may also be beneficial to patients with PD based on the possible mechanism via the microbiome-gut-brain axis.”
The Add-On Effect of Lactobacillus plantarum PS128 in Patients With Parkinson's Disease: A Pilot Study
One last thing I want to clear up for folks in the United States before I share our results. BenedLife has a patent on L. plantarum PS128 in the US under the brand name Neuralli. If you’re in the US, you can get L. plantarum PS128 from other countries under other brand names, but by the time you add shipping, the cost will far exceed what you will pay for Neuralli in my experience. Also, L. plantarum PS128 should ship refrigerated. That’s not going to happen if shipped internationally. I had to do a lot of research to arrive at this conclusion, but feel free to prove me wrong. So here’s your source for L. plantarum PS128 in the US: benedlife.com. Sure wish I’d known this before scouring the internet for hours looking for cheaper foreign sources.
Now to the purpose of this post, our experience with Neuralli aka. L. plantarum PS128:
There is no doubt in our minds that Neuralli is helping my wife in multiple ways. Btw we have been very strict in our testing by not introducing any new variables or changing her existing protocol in any way. We apply a scientific rigor and skepticism when we try a new drug, protocol, or supplement. We chart her progress as we go. We cannot explain the positive results we are seeing other than the introduction of Neuralli.
Clarity of thought and focus
- The first result we observed after about a month was an improvement in clarity of thought. My wife takes Neuralli at 7:00AM and 7:00PM every day. We have definitely seen an improvement in clarity of thought in the mornings, specifically verbal communication and cognition. We talk about important issues in the morning now and she has a complete understanding, focus and easy communication that used to take much later in the day to achieve.
Calmness
Along with clarity of thought she has experienced a sort of calmness we have not seen in years. A more stable, peaceful demeanor has developed. Delboy381 said it about his experience and we agree. She simply feels more “normal”, as unscientific a statement as this may be. All I can tell you is. She’s herself again; best way I can describe it.
IBS Symptoms
The most dramatic effect – and only after month 2 - is that her IBS and constipation symptoms dramatically improved. She used to take Miralax every night before bed to be able to go to the bathroom the next day. Now she rarely takes it at all. Every morning she goes to the bathroom once or twice. The diarrhea, constipation, gas and bloating have all but disappeared. None of the dietary changes or drugs she took for SIBO or her IBS previously have worked as well as Neuralli. And again, we know it’s Neuralli because she hasn’t introduced anything else or made any other changes.
Improvement in overall PD symptoms and medication requirements
There’s has been an overall improvement in her PD symptoms. I think this comes from the fact that when your gut, and consequently your immune system, starts to heal, you feel better in general. She now has more energy to exercise due to the healing of her IBS symptoms. Her motor symptoms – dragging her right foot while walking and occasional stumbling - have improved. This took about 3 months.
The other thing that’s happening is her need for medication has been decreasing. At first, we didn’t see a pattern in her daily medication requirements, but now we see in the morning, when she used to immediately require Sinemet upon waking at 5:30AM, she can now sleep until about 7:00 without any medication until she takes her first Neuralli with Sinemet at 7:00AM. This alone is remarkable.
Also, she takes Sinemet about every 2 hours during the day, but now we’ve been able to cut her pills in halves and quarters and give her less medication as a result. We’ve seen a change of .25 of a pill here, another .50 of a pill there at various times throughout the day, and yet she has the same or more energy. We’re down to about 6 25/100 pills on average a day now. These findings are very promising considering her trajectory was more pills, not less.
Conclusion
This is where we are after Month 6 and counting. We are so used to disappointment that we hardly ever use the word improvement anymore, but factually documented improvement unaffected by any other variable other than Neuralli is taking place. I have no idea what you will experience, but if you ask me if Neuralli is worth a try, I would say yes for sure, especially compared to all the other nasty drug alternatives out there. Hope this review was helpful. Any questions, please let me know.
you state that your wife drank probiotic ps128 at 7:00 a.m. and 7:00 p.m. Did she drink it in the morning together with Sinemet? Did she make sure to take it half an hour before the meal? Are there any side effects when drinking with L-dopa? Did you have a protocol? Thank you and best regards.
Hey delboy, for sure we are continuing. We're on a 3 bottle subscription plan every 3 months and recently started month 7. We'll probably never stop taking it, unless the effectiveness decreases or we experience side effects. Not likely with a probiotic though.
Wondering if you're still taking the PS128 and if you continued to have positive results. I don't see any recent update but am considering ordering it.
Where can I buy / what is cost / thanks clark I have read recent posts they claim 3 drifferent strains help parkinson's / you'll taking only one strain
I am just ordering 3 boxes for now. Cost RSD 8,940.00 (Serbia) works out to around £65 for 3 boxes of 30 caps. Its a Serbian website so had to do Google translate.
If anyone is following this thread, I want to say that I solved my constipation problem by taking 2 tablespoons of ground flax seeds and mixing them with yogurt every day. Best regards, Margot59.
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PS128 yoghurt "recipe"?
Probiotic, Solace PS128, Eases ‘Off’ Periods, Motor Symptoms in Trial (PRWEB) NOVEMBER 08, 2021
to the folks in UK, CUE1
Neuralli PS128 - How to take it
