A good, comprehensive discussions of PD, it's pharmaceuticals, & supplements.

[MBAnderson]

lifeextension.com/protocols...

[Zella23]

Thanks for posting Marc, it s interesting many of the supplements suggested are frequently mentioned on this website, and my husband takes quite a few of them. Good information on drugs for PD and how they work together and interactions.

[LAJ12345]

Thanks Marc. Seems this group is onto lots of these which is reassuring.

I’m interested they suggest a levodopa holiday for a week. (Pointing out the dangers so be aware of this before you try it).

[alaynedellow]

Brillint and very informative. Thanks v much Marc.

[Buckholt]

Excellent summary. The sort of paper which could be very helpful for the newly diagnosed.

I also thought the section on Levodopa holidays was interesting. Obviously not without risk, although this isn’t quantified, if it could restore future Levodopa response that is beginning to fail, then that is a very worthwhile topic for debate/research.

[chicagojoe]

Wonderful, thorough, if a bit overwhelming review. Thank you.

[WinnieThePoo]

I have a problem, Houston. I had bookmarked this as a reference to come back to. It has been cited on my thread comparing attitudes to Covid vaccine with aversion to conventional medicine

This article strongly promotes the use of Simverstatin as an anti-inflammatory neuroprotective on the basis of "ground breaking new evidence" in an article with a publication date of 2021

The "new" evidence is from 2010

Simverstatin was trialled and failed in 2019. parkinsonsnewstoday.com/202...

I just got a red flag up. Don't even start @parkbear on this one

[WinnieThePoo]

And then it promotes CoQ10... The dear departed CCL is your authority on this one but this articles interpretation of the results is diametrically opposite to most

pubmed.ncbi.nlm.nih.gov/278...

michaeljfox.org/news/coenzy...

It's one thing to disagree, but another to appear to be completely unaware of the material. This articles section on CoQ10 concludes by citing a 2008 animal study as "provide further evidence that administration of CoQ10 is a promising therapeutic strategy for the treatment of Parkinson's disease."

Uninspired

🥺

[MBAnderson in reply to WinnieThePoo]

I agree with you re Simverstatin and CoQ10. Keeping in mind, it's an article by a supplement manufacturer. I felt that overall, it's pretty good though. Do you feel an article that is this long, i.e., 98% of it's content is good should be disqualified because it missed the boat on these 2 items? (I suppose I should have noted my objections.)

I have raised these 2 issues with them. We'll see if they answer.

[WinnieThePoo in reply to MBAnderson]

Marc

I think you're right. It's a compact comprehensive review and in that context very helpful. I think some of the detail bothers me, especially the way some were apparantly interpreting it

[MBAnderson in reply to WinnieThePoo]

They answered.

Dear MARC ANDERSON,

Thank you for your recent communication.

First and foremost, thank you so much for taking the time to reach out to us at Life Extension and share your concerns regarding our Parkinson’s Disease Protocol. We take informed feedback from astute readers like yourself very seriously and consider it invaluable.

We agree that the discussions regarding statins and CoQ10 in our Parkinson’s Disease Protocol should be updated to reflect the latest evidence. So, we are going to undertake a thorough review of the published peer-reviewed literature and update these sections accordingly. We will add these updates to our editorial pipeline right away. We will also pass along the specific sources and articles you provided in your correspondence to the scientific writers and reviewers who contribute to these updates to ensure they are taken into consideration.

I will personally let you know when these updates have been published on our website, either directly or through our correspondence department.

Please feel free to email me directly if you have any additional feedback or questions about our Protocols.

Thanks again for reaching out.

Sincerely,

Blake Gossard, ELS, MWC

Chief Editor, Disease Prevention and Treatment

[e-mail]

[MBAnderson in reply to WinnieThePoo]

Richard, Thank you for calling these out.

[WinnieThePoo in reply to MBAnderson]

Can't say fairer than that! Impressive response