High doses of riboflavin and the elimination of dietary red meat promote the recovery of some motor functions in Parkinson's disease patient

[JayPwP]

scielo.br/j/bjmbr/a/BM4WLJB...

Motor capacity was measured by a modification of the scoring system of Hoehn and Yahr, which reports motor capacity as percent. All 19 patients who completed 6 months of treatment showed improved motor capacity during the first three months and most reached a plateau while 5/19 continued to improve in the 3- to 6-month interval. Their average motor capacity increased from 44 to 71% after 6 months, increasing significantly every month compared with their own pretreatment status. Parkinson's disease

[JayPwP]

Riboflavin Has Neuroprotective Potential: Focus on Parkinson’s Disease and Migraine

ncbi.nlm.nih.gov/pmc/articl...

Riboflavin is a potential neuroprotective agent. In fact, riboflavin has demonstrated its ability to tackle significant pathogenesis-related mechanisms in neurological disorders, exemplified by the ones attributed to the pathogenesis of PD and migraine. Indeed, riboflavin ameliorates oxidative stress, mitochondrial dysfunction, neuroinflammation, and glutamate excitotoxicity; all of which are involved in the pathogenesis of a wide range of neurological disorders.

[Smittybear7 in reply to JayPwP]

What dosage of riboflavin?

[JayPwP in reply to Smittybear7]

The Coimbra study used 30mg daily along with Vit D and Magnesium

Vitamin B2

Recommended dose in the protocol: Between 50 to 100 milligrams, 4 times a

day.

Best taken: With some food to reduce any gastric discomfort.

Daily total: Between 200 and 400 milligrams.

As noted in Chapter 5: "a study published by Dr. Coimbra and an associate in

the Brazilian Journal of Medical and Biological Research had the following

title: ‘High doses of riboflavin and the elimination of dietary red meat promote

the recovery of some motor functions in Parkinson's disease patients’

In this article, the researchers refer to another study showing that in some

populations, notably Florence and London, 10-15% of people have problems

with the metabolism of riboflavin.

[285] However, even those who don’t have this

metabolic issue can be deficient in riboflavin. For example, it is estimated that in

Europe the riboflavin deficiency levels can reach up to 20%.

[286]

Dr. Coimbra and his associate, Dr. Junqueira, solved the problem by

administering between 24 and 30 milligrams of riboflavin per day.

Due to the prevalence of deficiencies resulting from a deficient metabolism of

vitamin B2 and considering the important relationship between vitamin B2 and

vitamin D, vitamin B2 is, along with magnesium, essential during the high-dose

vitamin D protocol.”

You will notice your body is metabolizing vitamin B2 because your urine will

change color.

[park_bear in reply to JayPwP]

The study used 30 milligrams three times a day:

"30 mg riboflavin orally at about 8-h intervals (90 mg/day)"

[Bolt_Upright in reply to park_bear]

You seem to have a handle on this park_bear. Could you please lay out the protocol as you see it?

- 30 mg riboflavin orally at about 8-h intervals (90 mg/day)

And? B2? How much? Do I need Magnesium and D to make this work?

Thanks!

[park_bear in reply to Bolt_Upright]

B2 and riboflavin are the same thing. The only other intervention specified was excluding red meat.

[LAJ12345 in reply to Bolt_Upright]

Hubby has had a bottle of water with riboflavin dissolved in it for a few years which he sips over each day. He has only been taking 25 mg per day though. I suggest build up slowly if you are massively short of it in case it kicks off a whole lot of processes that find a deficiency somewhere else.

[Nguflh58 in reply to Smittybear7]

Said 30 mg every 8 hrs.

[Smittybear7]

Thanks for sharing

[park_bear]

Pretty good data although they did not use a placebo group. Worth a try since this is a low-risk intervention.

Note that they also excluded red meat from patient's diets. Not the only study found this was worth doing:

journals.sagepub.com/doi/ab...

[Bolt_Upright in reply to park_bear]

No more red meat for me

[Bolt_Upright]

It's interesting the paper mentions riboflavin being good for migraines too. Caloric Vestibular Stimulation is good for both migraines and PD.

[MarionP]

Intriguing.

[1953bullard]

I can’t find any B2 dosages that low. The lowest I see is 100 mg. How do they get 90 mg as high dose? Wonder if one 100 mg pill a day would work

[JayPwP in reply to 1953bullard]

Or break it into 4 pieces if tablet

[LAJ12345 in reply to 1953bullard]

nz.iherb.com/pr/natural-fac...

We use this one. You can open capsule and use half if you want

[1953bullard]

I ordered capsules so I’ll give one a day a try