Tendon issues

[Marcia123]

AnyoNe have tendon iSsues with Sinamet

[Resano]

The tendon issues seem to be there before one starts taking levodopa. I may be wrong but I tend to believe that the symptomatology has also been surrounded by some confusion related to muscles. Thanks to one of its key hormones, the pineal gland is supposed to relax muscles (and/or tendons?) during the night and facilitates contraction during the day. However, levodopa would apparently keep activating dopaminergic neurons around the clock...

[bassofspades]

Hello! I had a terrible time with tendonitis in my right foot. Specifically , the peroneus brevis and peroneus longus. I was down for weeks, recovered completely, reinjured and was down the second time for several months! And I don't recall having any real reason for the injury. All I did was brisk walking. It was awful. Finally, after weeks of physical therapy, I am back to brisk walking 3 miles a day and I have 20 lbs to lose that I gained from being immobile.

I was told that the tendonitis was a result of the stiffness associated with Parkinson's disease by my neurologist and physical therapist.

I had no idea that it could be sinimet related. Tell me everything you know about this correlation, please!! I am highly interested in learning more.

[Marcia123 in reply to bassofspades]

I have just started Sinamet and I could tell the impact immediately on my tendons in my ankle and my wrist even in my neck. I felt less stable and more likely to collapse. I have tried Sinemet three tablets several times and each time it has weekend my tendons. I also took Cipro and I understand that is not good for your tendons either but I only took two pills. I am not sure if there was a cumulative affect I hope I can rebuild my tendons and my muscles. I am down to 103 pounds at 5 foot seven. I am only six years old and I’m having difficulty walking and I don’t drive anymore and I would really like to get back to hiking biking walking. Everyone said Sinamet was the answer but I am not sure that is possible with what it does to my tendons. I would rather deal with the shakiness and be able to walk. Also I became more acutely impacted after I had a UTI Proteus mirabilis in November and tried a few antibiotics but I never stayed on them for the full course because each time it seemed to make my walking worse. I also may have lyme going on too. I wish there was one answer for everything z. This is very frustrating.

[bassofspades in reply to Marcia123]

Surely you didn't mean to say you are six years old ! You would think the sinemet would loosen things up and reduce stress on tendons. This is quite peculiar.

[Resano in reply to bassofspades]

Many PwP (have we been asleep for many years?) would share similar stories about Levodopa side-effects. First off, it is no surprise when you cast a glance at the related section of the package leaflet: a very long one mentioning, among others, freezing, hypotension, and even "isolated reports of melanoma reactivation" (Madopar leaflet).

This said, I am still confounded and dumfounded by the existence of research pointing out that Levodopa keeps activating dopaminergic receptors in the basal ganglia 24 hours a day, so to speak, and that would run against common sense because muscles (and/or tendons) are this way kept "relaxed" around the clock whereas they should only be at night...

Also: (already commented upon somewhere) : Levodopa, as a precursor of dopamine in dopaminergic neurons and of noradrenaline in noradrenergic neurons, would actually release as much noradrenaline inside the synaptic clefts of noradrenergic neurons as dopamine in those of dopaminergic neurons… Picture the nice consequences on blood pressure and heart beat...

[bassofspades in reply to Resano]

I asked my neurologist about the norepinephrine thing, because my bp has been elevated lately as I have been increasing sinimet. He said it was not correlated, in fact he sees way more instances of hypotension and orthostatic hypotension.

[Resano in reply to bassofspades]

Levodopa around the clock causes low blood pressure for the above given reasons. Your neurologist is correct if you asked what you said. I am afraid Sinemet is not the cause of your high BP. Please clear up the confusion.