Shilajit May Increase the body's producti... - Cure Parkinson's

Cure Parkinson's

19,965 members21,035 posts

Shilajit May Increase the body's production of uric acid

Bolt_Upright profile image

I'm just putting together two things that caught my attention (If you are not familiar with my posts, I am not a smart man so please don't embrace my speculation).

Shilajit May Increase the body's production of uric acid: verywellhealth.com/the-bene...

Uric Acid is lower in people with PD: ncbi.nlm.nih.gov/pmc/articl...

Our findings supported that lots of clinical and epidemiological data observed lower UA levels in PD patients. Manipulation of UA or its precursors’ concentration could be effective to treat or prevent PD. However, it is still suspectable that higher UA levels are better enough to PD patients. Furthermore, for the complex nature of PD and its heterogeneous genetic and environmental influences, it is inadequate for just manipulating UA in treating the disease.

Not at the top of my interesting supplements list. But on my list now.

5 Replies

Increasing uric acid is a mistake and can be disastrous. See my writing here:

Association ≠ Causation. Do Not Be Led Astray By This Popular Health Guru

tinyurl.com/ycsr4cfu

Well written park_bear. Now I'm going to make it look like I did not learn a thing :(

Oxidative Stress in Parkinson’s Disease: Potential Benefits of Antioxidant Supplementation 2020 hindawi.com/journals/omcl/2...

3.1.3. Urate

High levels of urate have been associated with a lower risk for PD [162], and changes in urate levels can predict the development of PD in animal models of the disease [163]. Coolen et al. [164], in a study with daily oral supplementation of 5000 mg of ATP in humans, identified that there was an increase in uric acid. In parallel, Andreadou et al. [165] detected the presence of reduced serum levels of this antioxidant molecule in patients with PD and suggested the potential use of this molecule in the therapy of the disease. Indeed, feeding a 1% uric acid diet to rats reversed PD symptoms [166], effects that may be related to NF-E2-related factor 2 (Nrf2) bound to the antioxidant response element (Nrf2-ARE) pathway [167]. Moreover, administration of inosine, a urate precursor, was safe and promoted improvement of PD symptoms in humans [168].

This is the study it references. It is from 2017:

One year safety and efficacy of inosine to increase the serum urate level for patients with Parkinson's disease in Japan

The question they did not answer was if there were benefits :(

Results

We did not observe any adverse events requiring termination or reduction of the study drug, although uric acid crystalluria was transiently observed in a single subject. An inosine dosage of 1070 (SD = 501) mg/day significantly raises the urate level from 3.5 (0.84) mg/dl at baseline to 6.68 (1.11) mg/dl at the 52nd week.

Conclusions

Inosine was safely used for one year and effectively raised urate levels in a small group of subjects. Our study is the first report to use inosine for patients with PD in an Asian population.

The final word on the matter was the futility halt of the phase III study that had been undertaken because of the kind of data you cited.. My writing from the link I provided:

"An extensive controlled phase 3 study was then undertaken – only to be halted for futility. A futility halt means the study was abandoned prior to completion because it was determined it would not show any advantage for the treatment [or possibly was causing harm]. This negative result demonstrates that the observed association between uric acid levels and Parkinson's was just that - association, not causation."

Link to futility halt: ninds.nih.gov/Disorders/Cli...

It takes observation over many years and a large number of subjects to detect the adverse impact of high urate levels. The trials of raising urate levels were of insufficient duration and size to detect this issue. Again from my writing, for example:

" All of the studies in this review [that found adverse effects] followed patients for more than 24 months and eight of them followed patients for more than 10 years. The relative risk (RR) of stroke of 1.47 that the review found is extremely high."

Do not be fooled. Raising urate levels does no good and invites disaster.

LindaP50 profile image
LindaP50 in reply to park_bear

Agree - plus uric acid can cause gout. My husband has swollen feet and ankles (not heart related) and doctor gave him water pills. Then, after a few weeks tested his uric acid and it was high - borderline for gout. A case where one RX pill helps one issue but causes another issue.

parkinsonsnewstoday.com/202...

Uric Acid May Help to Protect Neurons, Ease Non-motor Symptoms

You may also like...