Ketone Esters, Keto Diet, and PD and AD

[Bolt_Upright]

Good stuff on ketosis and ketone esters. Might need to add to the stack again

Focused on PD and AD:

ncbi.nlm.nih.gov/pmc/articl...

Summary and relevance statement

Most neurodegenerative diseases, including AD and PD, are associated with the key pathologies of mitochondrial dysfunction, neuroinflammation, and glucose hypometabolism and/or insulin resistance. Currently, there are no effective therapies for slowing the progression of either AD or PD. By addressing these core pathologies (and likely others), endogenously or exogenously induced ketosis might prove to be a novel and useful adjunctive therapeutic for these neurodegenerative conditions.

Focused on AD:

ncbi.nlm.nih.gov/pmc/articl...

Conclusion

KME-induced hyperketonemia is robust, convenient, and safe, and the ester can be taken regularly as a food supplement without need to change the habitual diet.

In treatment of TP’s long-standing AD dementia, KME-produced repeated diurnal elevations of circulating βHB levels were clearly effective, during the 20-month study, in improving behavior, and cognitive and daily-activity performance. The physician-caregiver noted that performance seemed to track plasma ketone concentrations, with conversation and interaction declining as levels fell toward baseline. From requiring almost constant supervision, TP became much more self-sufficient on KME. However, generalizability of TP’s partial improvement during KME treatment (it cannot be called a “cure”) remains to be determined by appropriately designed case-control studies.

[Bolt_Upright]

There is a clinical trial!

Effect of Ketone Esters in Parkinson's Disease

clinicaltrials.gov/ct2/show...

Brief Summary:

Ketones esters have shown to improve mitochondrial function and are currently use to enhanced functional performance. As Mitochondrial dysfunction is one of the proposed mechanism of neuronal injury in Parkinson's disease, the study aims to assess the tolerability,side effects and effect of oral ketone esters in Patients with Parkinson's disease.

[Bolt_Upright]

Ketone Esters cost a fortune!

And according to this video, ketone salts are bad and can make PK worse.

youtu.be/QO4WZIaoO7M(Not working as expected?)

[BootsOn]

Keto diet?

[kaypeeoh in reply to BootsOn]

When you forgo carbs the body is forced to use fatty acids for energy. They fit into the Krebs Cycle easily. I've heard that the ketogenic diet stops epilepsy. Anyone trying it needs to get urinalysis strips. They show whether you're in ketosis. But eventually the body will be able use be ketones for energy and the ketostrips no longer work.

[Bolt_Upright in reply to kaypeeoh]

Yes, the urine strips stop working and you need the blood meter.