Interesting article on brain reaction to virus

[felixned]

medscape.com/viewarticle/95...

This publication describes changes in the brain tissue of people who died after contracting COVID19 virus. Here is a small excerpt from the article:

"The most comprehensive molecular study to date of brain tissue from people who died of COVID-19 provides clear evidence that SARS-CoV-2 causes profound molecular changes in the brain, despite no molecular trace of the virus in brain tissue.

"The signature the virus leaves in the brain speaks of strong inflammation and disrupted brain circuits and resembles signatures the field has observed in Alzheimer's or other neurodegenerative diseases," senior author Tony Wyss-Coray, PhD, professor of neurology and neurological sciences, Stanford University School of Medicine, Stanford, California, told Medscape Medical News."

Is this another possible mechanism for PD start?

[Resano]

Hence the interest of High-Dose Thiamine for COVID-19 (Jeffrey Lubell)

hormonesmatter.com/new-deve...

[MarionP]

Very intriguing, will have to give it a good read. Meantime, sure, inflammation is a mechanism causes, exacerbates, in temporary or permanent, alone or in combination, a large variety of diseases, from a wide variety of external causes and our own normal, haywired, and triggered immune and programmed cell death processes. Many. Many many. "Overdetermined" is a term sometimes used to label an effect that has multiple simultaneous or sequential (and both) causes or inputs. Lots of those around. In fact one can profitably conceptualize just about every condition in terms of its constituent and substituent physical and chemical elements linked by their interaction and reaction mechanisms, and similarly the search to create effective interventions, by which I mean basically the literal physics and chemistry mechanics of practically everything, that's pretty much what most of science is about and where a great deal of it has been going to develop treatments and cures. Think tinker toys or lego or puzzles, or computer programming and machining, linked together in steps or sequences from a few to a few hundred or thousands, only on the tiniest of scales and in 3D...so yes, anything is possible because just about everything has already happened.

[MULTIVITZ]

Viruses aren’t contagious. The extensive sputum swap studies done in the 1930s debunks it totally. What you can become susceptible to is Disbiosis that provokes toxic release through various mechanisms.

I have to ignore the drivel by using discernment. But you get programmed do gooders that like the idea of censorship and other psychopathic ideas promoted by the corporations. You have to be drinking Aspartame twice a week to not notice!

The corporate system makes up industries, it floats ideas. Like war, drugs, entertainment, etc. Public interest is not a game, but it gets played through our media, life’s quite boring in reality. M

[Rhyothemis]

There are PD researchers who have suggested covid infection could trigger parkinsonism or PD: content.iospress.com/articl...

Though it seems that any acute infection or trauma could trigger PD, as this study found that a single surge in circulating lipopolysaccharide (LPS) induces brain inflammation for months after:

europepmc.org/backend/ptpmc...

OTOH, covid infection might be worse than most other infections/causes of inflammation. A preprint article reported loss of gray matter in some brain regions post-covid:

medrxiv.org/content/10.1101...

~

Wyss-Coray is a founder of Alkahest, which is developing AD treatments based on 'young blood' experiments. There has been some encouraging progress in that field of research recently.

[felixned in reply to Rhyothemis]

Immune protection of the brain is very robust,complex, and unique (different from other organs). The activation of microglia ( I would call them sacrificial cells) allows the immune system to preserve neurons with synaptic connections and thus preserves brain functionality. When neurons cannot be saved the brain can fix the damage by transforming astrocytes into neurons. I am not surprised that protection kicks in at the first hint of infection as you pointed out. In control theory we would call it a feed forward algorithm that tries to anticipate the future disturbance. It is an established fact that significant increase in flu infections corresponded with the spike in the number of new PD cases. You can find very interesting publication by Simon in his SofP blog. Almost any disease can be described as an error state of the immune response. It could be insufficient response when infection runs away unchecked or excessive response when inflammation is damaging cells trying to prevent something that will never happen. In polio 99% of the people who contracted the polio virus ( before the vaccine became available) fully recovered and many never had any symptoms. 1% developed paralysis. We still don't know why. I wish someone in the PD research community would try to look at the PD from this point of view rather than try to cure mice exposed to the neurotoxins that have nothing to do with PD or invest all of the resources into ASN hypothesis.

[Rhyothemis in reply to felixned]

Do you have a source for 'the brain can fix the damage by transforming astrocytes into neurons'?

Astrocytes can donate mitochondria to neurons, but AFAIK astrocytes do not convert to neurons. There was recent news of an experimental therapy that reprogrammed astrocytes to become neurons in mice. Neurons originate from neural progenitor cells and adult neurogenesis is limited to a few brain regions, it is not a general thing.

[Rhyothemis in reply to felixned]

Another possible route for damage was revealed recently in a study on C elegans - it is not known if something similar occurs in mammals. Apparently what happens in the gonads does not stay in the gonads.

advances.sciencemag.org/con...

I would not be surprised if covid infection sets off the mtUPR similar to protein aggregates. This paper reports alterations in ovarian function:

frontiersin.org/articles/10...