Link between p53 and Parkinson’s

[Gigi216]

doi.org/10.1016/j.cellsig.2...

Thiamine affects p53 binding to DNA

link.springer.com/article/1...

P53 involved in thiamine homeostasis

doi.org/10.1074/jbc.M104701200

[sharoncrayn]

glad to know you are into cell biology. P53 gene mutation research goes back at least 35 years (pre 1990) as it relates (links) to cancer.

for PD, read Cortopassi (1995) to start and work you forward to understand the complexity of this subject.

more recently, try:

Stress-induced p53 drives BAG5 cochaperone expression to control alpha-synuclein aggregation in Parkinson's disease. (2020)

by Chen HY, Lin CH, Teng, etc.

Sharon

[Gigi216]

Thanks, I briefly looked up some of Cortopassi’s work concerning quats, this will be my deep dive today, familiarizing myself with their work!

Gigi

[Kia17]

α-synuclein and p53 functional interplay in physiopathological contexts

ncbi.nlm.nih.gov/pmc/articl...

[Gigi216 in reply to Kia17]

Great article that gives information about the processes occurring! Thanks!