Is taking NAC, vitamin d, coq 10, magnesi... - Cure Parkinson's

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Is taking NAC, vitamin d, coq 10, magnesium theonate, & niacin a dangerous combination for someone with orthostatic bp ?

KERRINGTON profile image
17 Replies

I took them with dinner tonight, and nearly collapsed upon getting up to clear the dishes while experiencing an extreme niacin flush.

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KERRINGTON
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17 Replies
pvw2 profile image
pvw2

Pramipexole and Terazosin lower bp as a side effect.

KERRINGTON profile image
KERRINGTON in reply to pvw2

Thanks, I'll remember this in case they are ever prescribed to me.

rescuema profile image
rescuema

Niacin overdose will dump methyl donors so you need to be careful against being undermethylated. Visit the below recent thread for related discussions and videos.

healthunlocked.com/parkinso...

KERRINGTON profile image
KERRINGTON in reply to rescuema

Thank you...I've been reviewing your recommended videos and threads. You know so much ! I guess 100 mg of niacin for me is a bit much. For the time being I'll just take it in my b complex.

CaseyInsights profile image
CaseyInsights in reply to KERRINGTON

Be sure Nacin is in your B-Complex. It is not in most, because of the flush factor. healthunlocked.com/parkinso...

rescuema profile image
rescuema in reply to KERRINGTON

You could also try taking trimethylglycine (TMG) at an equal ratio for niacin (100mg for 100mg) to supply extra methyl groups. Be sure you're not deficient in B12 (sublingual better for absorption) either, which is another methyl donor. I do agree it's probably best to take a break from B3 overdosing for now.

MarionP profile image
MarionP in reply to KERRINGTON

Well as several have pointed out here, niacin is not included in any b complex. If you want niacin you have to take it as a separate supplement and play around with the dose, once you get the flush then back off a little.

KERRINGTON profile image
KERRINGTON in reply to MarionP

I was taking 100 mg niacin as a separate pill with dinner, with flushing coming every other night. I'm going to take less.

Hikoi profile image
Hikoi

I dont know anything about your supplements but post prandial hypotension is common in PwP.

Postprandial hypotension is a condition in which a person's blood pressure drops after they eat. (“Postprandial” means “after a meal.”) For people who have postprandial hypotension, the simple act of standing up after a meal can produce a particularly dramatic drop in blood pressure, leading to significant symptoms.

KERRINGTON profile image
KERRINGTON in reply to Hikoi

Seems I get the same problem after sitting in the sun.

Hikoi profile image
Hikoi in reply to KERRINGTON

Yes and for a similar reason

Dizziness and fainting results from reduced blood flow to the brain.

Heat causes an increase in blood flow to the skin and pooling of blood in the legs, which can lead to a sudden drop in blood pressure. In postprandial hypotension blood supply is concentrated in the gut where the food is being digested.

MarionP profile image
MarionP

What ALL else do you take and how much beside these? Also how much niacin do you take? have you ever had a niacin flush before?

Also taking all those with dinner may not be related, it may be the dinner itself that is related... If you have postural hypotension, once you have started digesting, at that time much of your blood supply is directed toward your stomach and gut, which means you may have proportionately less blood available in circulation to compensate for when you stand up especially abruptly. An illustration, not to compare you with my Samoyed dog but Samoyeds are not allowed to move much after eating a meal, and must rest for roughly an hour or they risk characteristic twisting of their bowels which can be dangerous for them. we've been lectured by our vet and our Samoyed owners club for a while about the actual danger, and you wouldn't suspect it it's not something you naturally think of.. .Taking on a big load of calories in general causes some demand on your blood supply for a while. Reminds me of the Six Day War.

KERRINGTON profile image
KERRINGTON in reply to MarionP

I'd never be offended to being compared to man's best friend, especially a Samoyed..We use to have one in our neighborhood named Loki. Because I always pet him, he never went past my house without stopping to sit and face the house till I would come to to pet him. What a doll..By the end of the day I've had 1 Avmacol ( broccoli seed extract), a low dose quality food sourced B complex with minerals, 300 mg mag theonate, 1k vitamin C, 10,000 iu vitamin D3 K2, 375 mg B1 2X daily, 300 mg NAC 2X daily, 100 mg COQ 10, and 1000 mg dopa extract Mucuna puriens, and 1 teaspoonful of mannitol.I'm off niacin for now, and yes I always get a severe flush.

Vegegardner profile image
Vegegardner

I think That B3 can lower blood pressure.Or you may have to be careful of high dose if you have low blood pressure.

I'm not sure. But I saw a lady once go down in bed half a day on 500 mg niacin. She had low blood pressure issue. I found out later..

rescuema profile image
rescuema in reply to Vegegardner

This is true. Niacin does cause acute vasodilatory effects during flushing lowing BP. Overdosing can also cause liver, kidney, heart arrhythmia as well as a significant increase in the potential for diabetes - all linked with methyl depletion.

glenandgerry profile image
glenandgerry in reply to rescuema

Do you think the same is true for Nicotinamide Riboside?

rescuema profile image
rescuema in reply to glenandgerry

Yes NR will also deplete methyl donors, especially at the typical high dosage.