How stem cell therapies actually 'work'

[Rhyothemis]

.... and how stem cell-derived treatments in the near future will not actually involve injecting stem cells into people.

youtu.be/tOs0PCP9B8Q(Not working as expected?)

keywords for the HU search engine: regenerative medicine, exosomes, vesicles, cell-free therapy, Duchenne muscular dystrophy, heart failure, cardioshphere derived cells, RNA, IL-10, fibrosis, inflammation, oxidative stress, Eduardo Marbán, video, presentation, lecture

[Rhyothemis]

Uploaded just today, the researchers and also Lab Roots are working

really hard - uploading on Boxing Day) - kind of a technical discussion,

but it shows the level of interest in the technology: youtu.be/uZXzZ13Ikj0(Not working as expected?)

[Rhyothemis]

Research article on exosomes for PD - in vitro and rat model . They showed the exosomes can cross the BBB:

nature.com/articles/s41419-...

[sharoncrayn in reply to Rhyothemis]

"future studies are warranted to determine the mechanisms underlying hucMSC-derived Exos-induced neuroprotective effect."

[sharoncrayn in reply to Rhyothemis]

The issue in the future will be how and if an extraction process can be developed that is efficient. So far, we are years into its development, and they still will need stem cells to make it.

Because of their transfer capabilities with mRNA proteins, perhaps they also have application to Covid-19. Who knows?

Sharon

[movinngroovin]

Where is this being done?

[Rhyothemis in reply to movinngroovin]

Exosome preclinical research and clinical trials are being conducted worldwide. There are currently no clinical trials for exosomes for PD, just preclinical research (rat & in vitro experiments). There are clinical trials for other diseases, though.

Here's a PENDING trial for pancreatic cancer by the very reputable M.D. Anderson Cancer Center in Houston:

clinicaltrials.gov/ct2/show...

Stem cell clinics in China are racing ahead with trials and I hope they are conducted ethically and produce reliable results, but they do seem a bit sketchy since some of the regular stem cell trials listed in clinicaltrials.gov for these clinics seem like adverts. Here's a study BEING CONDUCTED in China for covid using inhalation of fat stem cell derived exosomes: clinicaltrials.gov/ct2/show...

Beware of clinics claiming to offer exosome therapies right now that have not gone through the clinical trials process:

"Unfortunately, disreputable commercial clinics are cashing in on the

hype, peddling unproven “cures” for numerous conditions, based on

exosome preparations of questionable provenance. “These exosome mills

are sprouting up all over,” says Chopp. Exosomes are much easier and

cheaper to generate and handle than stem cells, and have fewer immediate

safety concerns than cell therapies, he explains. And that makes them

an appealing alternative for unscrupulous medical practitioners looking

for an easy profit. And the steady trickle of exciting progress in

preclinical research provides ready fodder for marketing. “I even get

some of my papers cited in their brochures,” says Lim. These unregulated

clinics routinely make claims that go well beyond the available

preclinical data, and sometimes border on the outlandish. Indeed, a New

Jersey-based clinician and Kimera Labs, an exosome producer in Miramar,

Florida, ran foul of the US Food and Drug Administration (FDA) in April

2020 for offering exosomes that they said could prevent or treat

COVID-19 — claims that have since been struck from the company’s

website."

nature.com/articles/d41586-...

[sharoncrayn in reply to Rhyothemis]

NO results posted per the CT your cited. Why don't you write and ask for an update?

[Cagey84 in reply to sharoncrayn]

The first CT won’t finish until 2022 and the second is in “results submitted” status with clinicaltrials.gov

[sharoncrayn in reply to Cagey84]

Well, let's wait and see if either one publishes. I have my doubts about the MD Anderson one. Very difficult when you are looking at OS for Pan C patients. Let's hope it works.

[Rhyothemis in reply to sharoncrayn]

The point was that trials for cell-free therapies are already being conducted and more are scheduled.

[Rhyothemis in reply to sharoncrayn]

I edited the post with ALL CAPS on the important words since, following your example, it apparently ENHANCES MEANING.

[Gioc in reply to Rhyothemis]

It can happen .... sometimes.

Sometimes a good duplication of symbols helps understanding,

but I don't think this is the case ...

Nothing serious...

LOL