Excerpt “For more than ten years, Dr. Antonio Costantini and his colleagues in Italy have used high-dose thiamine to treat a range of neurological conditions. While they seem unaware of its CAI properties, the dosages they use (for most conditions, 600 to 1,800 mg of thiamine daily, rising to 4,000 mg of thiamine daily for Parkinson’s Disease, in divided doses) are precisely those needed to reduce cerebral spinal fluid flow in light of the findings of Ozdemir et al. (2013) and Smithline et al. (2012). As I will explain in more detail in a subsequent post, I believe carbonic anhydrase inhibition provides a plausible explanation for the outcomes Costantini and his colleagues have observed, potentially in synergy with other pathways.”
Interesting article. I just wanted to mention it again, that high doses of thiamine HCL give me a very high blood pressure. Have not been able to find anything about it in publications. It did not happen right away, I got great benefits from Thiamine HCL. So now, I have reduced my dosage to 500 mg per day, or less. Sometimes I have to stop it completely for a short time. I have heard of a few other people, maybe three, that had the same problem. Just wanted to mention it, in case somebody new is trying thiamine HCL.
I read the article and notice that Thiamine has a half life of three to five hours. I am not sure what that means but I wondered if it implies we could divide our doses into three instead of two. I feel the positive benefits for the first few hours and had wondered if there is a wearing off. I now take 2500mg divided into two doses. I've been taking it for two months.
obviously there are some benefits to the administration of thiamine for this reason it is used by extreme mountaineers to give immediate energy and also in the emergency room to resolve alcoholic crises in a few minutes, but it also has an effect on the mind by restoring the most vivid memories. Certainly these positive effects are related to the half life of thiamine in the blood which is precisely 4/5 hours as mentioned in the article. Moreover, thiamine participates in many cellular, respiratory and enzymatic processes in many organs that are less subject to thiamine fluctuations in the blood and which as a result give what Doctor Costantini called the "restorative effect" i.e. the part of dopaminergic and suffering brain cells, but not yet dead, they would have had a recovery with thiamine. A much more solid effect not subject to daily fluctuations. but certainly the extent of the PD brain injury will play a role.
Thiamin (vitamin B1) is a water-soluble vitamin that is absorbed in the jejunum. Without regular and sufficient intake of thiamin, the brain, heart, muscle, liver, and kidneys can rapidly become depleted of thiamin stores. The half-life of thiamin in the body is only 9–18 days, meaning that a person can become deficient in thiamin stores over a very small period of time. Thiamin stores in the body are relatively small and replenishment must occur daily. A deficiency in thiamin levels for a week, accompanied by persistent vomiting, can rapidly deplete thiamin stores.
Winnie what you write is correct. But there was talk of plasma half-life defined as: The half-life (t 1/2) is a pharmacokinetic parameter that indicates the time required to reduce the plasma (blood) concentration of a drug by 50% “. This is what we look at when taking a drug to avoid excessive overdose, in the case of levodopa and Thiamina too it is short and this creates some problems for us.
In the organs of the body only little thiamine is stored with good nutrition we would never be deficient , right? However, it must be considered that the concentration of vitamins in the body is not uniform, some organs such as the liver or the brain need them more and easily become deficient by burning all the local thiamine. In this case, the occasional additions of thiamine in high doses could solve the problem also considering the difficulty of transporting the thiamine itself.
The accuracy is relative to the brevity of the post.
I have been taking it for 5 years now in order not to hurt the reality of the "impossibilists" ( word invented by me from Italian ) I will not tell all you that I am sick almost exactly as before.😀
Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.
Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.