A Hidden Cause of Resistant Depression

[Kia17]

Folinic acid is an advanced folate in the folate metabolism cycle and is used in mitochondrial respiration, making DNA, and making methylfolate, which is in turn used to make neurotransmitters and to help recycle folate and methyl groups. Folinic acid rather than methylfolate is preferred in these patients because it covers problems above and beyond those with just methylfolate deficiency and can also bypass the problem of antibodies to the FR1 receptor that could underlie the deficiency in the first place.

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