Giving “Tru Niagen” another try

[Kia17]

I have been searching in finding ways to minimise my exertional dystonia which has been my main symptom from the beginning. I started taking Tru Niagen 125mg x twice a day for the past few days.

Last year when I started taking Tru Niagen , It only gave me a rush of energy so stopped it after a few days.But now I noticed that It helps my exertional dystonia. It’s too early to conclude but I will keep taking it for sometimes and will observe the results and post here.

Any idea about the dosage?

[gaga1958]

I've been taking according to the box which is 150mg per capsule. I have not noticed any benefit. I've been taking approx. 3 mon

[Kia17 in reply to gaga1958]

Thanks for sharing Art.May I ask why did you use the Tru Niagen?

[gaga1958]

this is what tru Niagen told me about their product when I asked them to compare to CoQ10...…………………...

"Thanks for writing to us. You asked a good question. NIAGEN® works by providing a substrate for NAD+, a transport molecule that carries output from the Krebs Cycle to the Electron Transport Chain. This occurs inside mitochondria. CoQ10 as ubiquinone or ubiquinol, is another co factor used to transport electrons and, as such, contributes to cellular energy production.

Although all both of these supplements are used to increase cellular energy production, they operate through different mechanisms of action, and therefore can be used in tandem to provide a synergistic benefit, without creating redundancy."

Sincerely,

Cheri Thomas

[jimcaster]

I don't know if TruNiagen will lead to any immediate, noticeable improvements, but I think it's a safe long term investment. In accordance with a study now underway, I take just over 1,000 mg per day. I take some comfort in knowing that Parkinson's News Today named the use of nicotinamide riboside as the top news story of 2018.

parkinsonsnewstoday.com/201...

[Kia17 in reply to jimcaster]

Thank you Jim

[chartist in reply to Kia17]

Kia,

In a post above you asked me a question about Tru Niagen that does not apply to me because I have never used it.

I do agree with Jim in that it seems that a study I saw a while back used at least 1,000 mg per day which makes the use of Tru Niagen quite expensive if you are trying to replicate the study and dose (1,000 mg) that gave the largest increase in whole blood NAD+ . A 100 mg dose gave only a 22% increase while a 300 mg dose gave a 50% increase and the 1,000 mg dose gave a 142% increase. In order to get close to the higher dose of 1,000 mg per day, you would have to take 7 of these per day at 150 mg per capsule and each capsule costs about $.75 x 7 per day = $5.25 per day x 30 days = $157.50 per month x 12 = $1,890 per year. Here is a link to one study at these doses :

ncbi.nlm.nih.gov/pmc/articl...

Btw, on this forum, you are the first person I have heard actually say that you got a real benefit from taking it, in that it helped your mild dystonia . Regarding that, do you think the mag oil or the Tru Niagen was more helpful in terms of the dystonia in your toes?

Art

[Kia17 in reply to chartist]

Hi Art

I mixed chartist with chrisz. My bad.😐

I am also using Mag oil before cycling. It’s helpful but not measurable. I keep using magnesium oil as well. Thanks

[chartist in reply to Kia17]

Yes , but I am asking about the difference between the two in terms of helping the dystonia in your toes? You only mentioned mag oil twice.

Art

[Kia17 in reply to chartist]

I was taking Mag oil for cycling in the morning before starting to take NR and it wasn’t helping much. Now I take NR and magnesium oil before cycling and I noticed that the frequency and the duration of dystonia ( toes curling down or up) decreased.

[Kia17 in reply to jimcaster]

Jim

Each capsule is 125mg , so You are taking 8 capsules of Tru Niagen a day. Morning 4 capsules and afternoon another 4? Am I right? With meal or without?

[jimcaster in reply to Kia17]

The capsules I take are 150 mg. I take 4 each morning and 3 each afternoon on an empty stomach.

[rebtar]

Laurie Mischley has had some success prescribing lithium orotate for dystonia -- I am not sure about dosing. Her Master's thesis was about lithium deficiency in P.D. Interesting.

digital.lib.washington.edu/...

I know she tests for lithium in all of her patients and that many PD patients have a lithium deficiency.

[Kia17 in reply to rebtar]

Thanks for sharing. I have tried lithium Orotate but it worsened my dystonia.

[LAJ12345]

My hubby has just started again. He has taken the natural factors one before and I’m not sure if there was an effect or not. Now apparently the tru niagen is the only one you can get as chromadex who make it and have the patent don’t supply any other company any more.

[Kia17]

Anyone know why do researchers in recent clinical trial ( Nicotinamide riboside) in Norway have used 1000mg daily (2x500mg). Why not less or more? Is it based on individual’s weight? How did they calculate the dosage? Thank you

clinicaltrials.gov/ct2/show...

[Kia17]

I just wrote to the research team in Norway and asked why they have chosen to administer 1000mg NR daily.