Very interesting study about cannabis - Cure Parkinson's

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Very interesting study about cannabis

1953bullard profile image
8 Replies

linkedin.com/pulse/cannabin...

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1953bullard profile image
1953bullard
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chartist profile image
chartist

1953bullard,

If they are correct, chronic users of "the chronic" should never get PD???

That seems like it would be fairly easily studied and determined to be true or false. A simple questionnaire to all PWPs who have been users of the chronic for many years.

Art

Pats68 profile image
Pats68

Is this referring to just Cbd or does it have to include THC?

1953bullard profile image
1953bullard in reply toPats68

It’s specifically says marijuana so I’m assuming thc.

MarionP profile image
MarionP in reply to1953bullard

Well, how can you actually assume ANYTHING? And more to the point, why would you want to?

chartist profile image
chartist in reply toPats68

I think the following three sentences from this report suggests that any of the active components in marijuana are included in the potential to interact with our cannabinoid receptors, of which we have many. CBD, THC and CBN would be three well known ones that would surely be included as studies show that all three have some pretty specific effects in humans,

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Cannabinoids refer to any of a group of related compounds that include cannabinol and the active constituents of cannabis.

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The human brain contains an extensive network of special receptor sites that modulate nervous system function only when activated by the appropriate cannabinoid compounds, which are found in the marijuana plant.

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The body regenerates best when it's saturated with Phyto-Cannabinoids found in cannabis.

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Clearly, they could have been more specific in their descriptions.

Art

MarionP profile image
MarionP

royalsocietypublishing.org/...

John_morris71 profile image
John_morris71 in reply toMarionP

From the link to the article you provided.

'Cannabinoid treatment effectively attenuated the loss of dopaminergic neurons in rat models of Parkinson's disease [160,161] and proved to be neuroprotective in human neuronal cell culture exposed to Parkinson's disease relevant toxins [250]. The authors suggested that the anti-oxidative effect and suppression of microglial activity by cannabinoids together play a major role in these models [161,251]. The three published clinical trials in Parkinson's disease patients did not provide a clear answer whether cannabinoids modify the progression or the outcome of the disease. A double-blind, placebo-controlled crossover study that tested the symptom relieving effect of cannabis testing nine patients reported a significant reduction in levodopa-induced dyskinesia [252]. The following two clinical trials using a larger number of patients could not find any improvement in levodopa treatment induced dyskinesia or parkinsonian motor disability using cannabis [253] or the CB1 receptor antagonist rimonabant [254].'

MarionP profile image
MarionP

Well, I just put up the reference referred to, without comment, so people could read it rather than get bits of it secondhand and filtered or selectively emphasized or shaded. People are responsible for their own read; no problem with that of course.

But all depends, unavoidably, on the actual specific definition of terms ("neuroprotective," "effectively," "attenuated," "loss," "suggested," "play," "role," etc.). You begin to get the point. Any one of these and many others that isn't nailed down and still resulting in the hoped for direction result is enough to scotch the whole immediate usefulness of the info, rendering all of it extremely premature. It's actually like that with many things. Doesn't stop one from trying this or that and in their own sample and procedure of one, finding out what they find out. A great example of that is Dr. C. and his HDT. Another: really fortuitous experiences with mucuna, very impressive, despite a lack of organized science.

But effective consumption of research is not something you just pick up (sadly, wish it weren't so, but nonetheless it is the case). One twist of the direction of a single atom in a molecule made up of hundreds of components makes the difference between a necessary beneficial food and a deadly chemical weapon.

Also qualification: the specific formulation, and delivery, of the cannabinoid treatment substance; the specific definitions of the measurements and the interpretations of the results, followed by multiple replication or failure to replicate by independent researchers, followed by larger scale studies, then followed by well designed large scale studies in humans. Anything less than these aforementioned qualifications constitutes bold naked sales pitches hope-talk intentionally pitched to desperate or naive (not intentionally, not a fault, just uninformed or unequipped to be informed from this kind of source) rubes...adjectives that mean little, wiggle words with tons of wiggle room in them, and all pending proof, proof. Because just something to remember in human nature and all economies: no matter the field or profession or trade: "Everybody Sells."

That said, yes, it is definitely interesting.

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