Very interesting article by Dr Laurie Mis... - Cure Parkinson's
Very interesting article by Dr Laurie Mischley
"For my patients with Parkinson’s, I tend to give 5–20 mg per day of lithium. But that is a huge area of research—how much do we actually need? And do some people need different amounts, depending on where they live or during a particular period of their lives? For example, I have found higher doses to work fairly well for Parkinson’s dystonia. When somebody goes up to 40, 60, or even 300 mg per day, they tell me that their toes are no longer curling, or that they can walk without cramping up.
...
In my own research, we are following 2000+ people with Parkinson’s from point of diagnosis forward. Our results very clearly show the more dairy people eat, the faster their disease progresses.
...
People who are taking iron supplements are progressing faster than people who are not....
The fortification that is happening in grain products is essentially like taking an iron supplement. I am actually surprised at the number of people who are coming up with high iron. And as soon as they stop eating fortified grains, the numbers come right down. It is easy to make sure your patients are not taking a multi with iron, but it gets a little more complicated when you start looking at fortification. I’d estimate that approximately 1/20–25 people are elevated, and that comes down as soon as they stop eating fortified breads and processed cereal."
Also, intranasal glutathione seems to be helpful (although personally it never did anything for me).
To Contact Dr. Laurie Mischley
Website: EducationIsMedicine.com
E-mail: lmischley@bastyr.edu
Very interesting and informative article, thanks for reporting. On page n. 64 of the same article, the author refers, I think, to the protocol of Dr. Costantini, even if she does not mention it.
Always interesting insights from Dr. Mischley. I am both a fan of her work, and a patient of hers.
She doesn't recommend NAC. Comments?
I disagree. There is a very long list of things NAC has been shown to be good for in studies published in medical journals. It is FDA approved for treating liver toxicity. It is a mucolytic used to relieve lung congestion. It has been safely injected in high concentration into the ear to protect against chemotherapy toxicity. It relieves prostate inflammation. I use it in a toothpaste formulation to break up bacterial biofilms. And of course it has been shown to improve Parkinson's. This is as close to a real life miracle substance as one will ever find.
Hello park_bear ! Can you tell me how much NAC you take a day ? Pills , drops or in another form ?
And related to your body weight ?? After or before the meal ? And which brand ?
Which toothpasta do you use ??
Thanks in advance !! (tomorrow again to the dentist, double check if a wisdom tooth deep in the mandibula could have an influence......and if tooth 26 (former broken
amalgam filling) could be "tested".......
Very informative article, thank you for posting. As an adjunct, below is a link to a 56 minute update on her research presented by Dr Mischley to the Parkinson's Society of British Columbia in June, 2018. Enjoy!
This is what I found most interesting:
"It is absolutely fascinating, as we are starting to see. We are publishing our findings as fast as we can. Some of the biggest variables associated with fast Parkinson’s progression are being lonely, being poor, getting a bad night’s sleep, and not exercising. When you step back and think about what that means for public health, it is hard to not have your jaw drop when you really think through social health and isolation and income inequality. And it does not surprise me in light of the data that I am seeing that we have an increasing pandemic of Parkinson’s disease.
It seems to me that loneliness and sedentary lifestyles are becoming increasingly more common in modern society. It is going to be hard to put a solution for that in a pill that can be sold by big pharma!"
We didn't met the criteria, but still. . . Parkinson's it is!
How are you doing, Sunvox? Still on True Niagen?
Hi Despe,
Yes still taking TruNiagen. I update my total regimen with my latest changes on a regular basis: healthunlocked.com/ataxia-u...
You should have a look 
An interesting side note for me that comes as a direct result of this thread, I am now going to add Lithium Orotate to my list of supplements. Dr. Mischley got her start in Parkinson's research looking at the role of lithium, and after reading her comments in the article I have spent this morning researching the topic, and it is clear to me that lithium is another supplement that probably plays a tiny part in the overall health of cells in the brain. As with so many other supplements when studied individually the efficacy does not meet the level that researchers can see using the standard technique, but the fact that secondary outcomes DO show influence leads me to believe lithium is another important mineral lacking in the brains of people with neurodegenerative diseases that stem from toxic expanded proteins. I also see folks here have been talking about and taking lithium for years.
Lastly, I think everyone with PD should avail themselves of Dr. Mischley's new method of measuring their disease: redcap.bastyr.edu/redcap/su...
Happy Easter everyone
Joe
Belated Happy Easter to you, too! I was out most of the day so this is my first opportunity at checking my email and HU. 
My husband and I had our first telemedicine consultation with Dr. Mischley a few days ago. Follow up late May when we are going to discuss more extensively about therapy protocol, including supplements/vitamins/nootropics. I know she encourages lithium orotate supplementation. Actually, I thought about it long before I realized she recommends it to her patients. 
My husband answered her PD survey and emailed it to her before our appointment. Interesting. . .
"0.1 g sniffed once weekly of powdered mannitol" Are you still sniffing powdered mannitol? My guess is that it enters the brain easier than the oral route.
I haven't searched ataxia but its symptoms as you describe them are almost identical to PD.
Thank you!
Also from the article:
"There is a neurologist who is supporting the use of very high doses of intramuscular thiamin. It is so important to keep in mind that when someone experiences hope and excitement and enthusiasm, they make dopamine. There is a lot of research that says the more invasive the intervention, the stronger the placebo response."
That fails to explain why one form of thiamine improvement occurs after a week or two yet other forms of improvement take months.
Hi Marcet. I am a huge fan of Dr Laurie. Her Lagotto Romanagnolo smelt me out a couple of years ago and I have had very high hopes that Dr Laurie will achieve her goals.
I have a couple of questions and a couple of observations:
I was diagnosed with lactose intolerance in the early seventies. I love cheese and was most put out by that diagnosis. If I ate cheese I got such stomach pains and diarrhea that I could not touch cheese for many years. That changed many years later when I ate some cheese without getting the problems. I was diagnosed with Pd in 1992 but my first symptom started in 1963 when I was unable to let go of a ball or dart properly, when trying to throw it. (Coordination)
Constipation has been longest-lasting symptom. On that score I have always regarded it a a muscular problem because the muscles around the intestines do not move the stool on to the rectum. I have the same peristalsis problem with chest infections. Why does Dr Laurie not treat either of those symptoms as muscular problems?
Dr Laurie does not mention GDNF as a major factor in the treatment of Pd. The study carried out by DR Gill in Bristol in 2003 proved that GDNF improved the symptoms of all 6 participants. As GDNF is a natural product of the brain, should we not be looking for ways to get the brain to produce more GDNF? I think I do this in my brain by doing FAST WALKING every second day, which I THINK causes the brain the go into 'FIGHT OR FLIGHT' MODE because most of my symptoms have improved to the point where I have been able to come off all Pd medication since 2002 and have lived a normal life since then. If it wasn't what I think then what does she think caused the improvement in my condtion?
Insomnia has been a problem for me since 1974, 20 years before diagnosis. My average sleep per night was less than 4 hours up till 2010. Since then I sleep an average of around 5 hours a night. Does she think cannabis oil will help me?
When we met, did I not explain to her how I have managed to take conscious control of many of my movements including walking and writing? I have bypassed the substantia nigra and do most things as well as I had before, but a lot slower. Having said that, I stilll manage to walk 7 kilometres in an hour at the age of 84!
Are Fava beans available in health shops and if so, are they expensive?
Oral high-dose thiamine restores intestinal peristalsis.
Fava beans are readily available at reasonable prices.
Nobody seems to be zeroing in on the cause of Parkinson's. There is always a cause, there is a causative agent and nobody is talking about it or looking for it. I strongly believe it is some kind of a virus. A virus that hasn't been discovered yet because nobody's looking for it.
It could also be borrelia burgdorferi (Lyme) which has different strains and may have numerous co-infections carried by ticks - so, I believe a combination of those with some susceptible gene variants can cause PD. Unfortunately, spirochetes can lay dormant for years and then attack different organs causing variety of symptoms which are hard to track back to a single infection, especially if the tick bite went unnoticed. But Lyme also can be carried by mosquitoes, horse flies, etc. which most of us have been victims of.
I had Lyme disease with a co-infection. At present I don't have it, dr. Anthony Smith of Coeur d'Alene Idaho got rid of it. For a longest time I thought maybe my Parkinson was result of Lyme disease, however I do have Parkinson's disease That has nothing to do with Lyme disease.
I agree with you, parkie13. If you know the cause you can diagnose the disease, prevent it, possibly cure it. I also think that virus infection is the cause. If you look at my earlier post you can find reference to the publication by British researcher Dr. Dourmashkin where he claims that he found enterovirus in the brain cells of 14 people who died with the Parkinson disease. One would think that lots of people would pursue this discovery. Nothing of the sort! Nobody wants to look further. I periodically communicate with dr. D and he says he'll publish more detailed article. Enteroviruses btw live the gut (did someone mention micro biom ? ) many are human specific , and these viruses are responsible for such illnesses like polio . Polio virus infects many but doesn't cause disease. Only 2 percent of the infected develop chronic disease with paralysis . Is it because of some genetic defect that is making immune system ineffective in some people ? We probably will never know since polio is practically eradicated.
Few days ago I heard on the news that they found the virus that causes a polio like paralysis in children. Some of the children are not getting better. I also think that our liver is very much involved in Parkinson's. A while back I read an opinion on the state of research in this country. The money is very hard to get, the people that get the money even though the research has already been done just redo it. That's way the money is not applied to something that might do good. As far as the Parkinson's becoming a pandemic I think we have a big enough pool of people that are infected and it is spreading to other people. It's not an extremely easy virus to get however it is spreading. There are researchers ringing the alarm however nobody is listening to them. Also they are ostracized by other researchers and the news people. We live in a very scary world.
Here is doctors dr. dourmashkin study, very interesting reading, it also has electron microscope shots . ncbi.nlm.nih.gov/pmc/articl...
It's funny you should say that! Nobody is looking for the cause, although we know that several chemicals can and do cause Pd, such as mercury in teeth fillings, pesticides ingested and at time of spraying crops and several others.
The other peculiar thing that nobody is looking for is the reason why fast walking has reversed most of my Pd symptoms.
I can understand why nobody is looking for the last reason but the first one is definitely a mystery.
I do believe I had mentioned elsewhere here, with references, that certain virus infections (spanish flu and a current, I think H1N1 flu, in actual experimental examples) are known to destroy, nearly completely where they touch, wide swaths of cells in substanta nigra and other areas highly important to development of dementias, experimentally introduced in mice. Now the fact that the final anti-biotic class still known to work against bacterial resistance has been breached can't help. Next, there is the universal encroachment of environmental pollution, particularly of drastically powerful agricultural and industrial chemicals and heavy metals that make it into our water and produce and agricultural products which end up in food and then in us, where they accumulate as too difficult to eliminate as fast as they inculcate and gum up various works...my favorite example being the use of fracking oil well waste water to irrigate large lands growing the bulk of produce in the great California agricultural valleys, where the oil is next door aplenty and the water for 45 million people, industry and agriculture is quite dear...environmental pollution is across the entire world thanks to the power of corporate concentration to control impediments...and the substitution of denuded processed food and synthetic vitamins for the real thing...added of course to aging. Then there is the nearly universal infection of humans by the "cat virus" colloquially known as toxiplasmosis, most likely unleashed when for whatever reasons people's immune systems become weakened past some point. Sedentism and saturated/animal fats do their work on the vasculature, interrupting healthy blood perfusion to brain cells generally; quite aside from genetic weakness in the genome distribution for some, but not all, individuals as nature provides. Finally, the cellular and dna damage done by oxidative stress of various sources add their accumulated effects.
Plenty of reasons to go around. The key is developing solutions that can be traced and then manipulated at the mechanism level, otherwise systematic treatment across the population is always bound to be hit or miss and experienced as idiosyncratic for the foreseeable future. Certainly hopeful, and when you find something that works, you enthusiastically use it, because once drug manufacturers come up with something, it will for certain be as expensive as they can make it for as long as they can keep it so.
Thank you. Long but very interesting, especially p 65 where she gives her 5 top supplements.
Makes a good read. Still a long way to go. Considering the number of supplements that are beneficial to the brain/nerves, it is almost impossible to find the right combination and dosage to see significant improvement. Not trying to be negative here, but this disease seems to get more complicated when looking further at the gene and molecular level.
Interesting how everyone cherry picks their favourite bit. I was very impressed by the video of her lecture about nutrition, and have used it as the basis for my own nutrition. At 10.26 she produces a chart of foods which cause faster progression of pd (red), neither faster nor slower (blue) and slower progression (green). She refers to studies showing dairy to cause faster progression, but that the findings in her statistics "according to these data, dairy is NOT associated with a faster rate of progression". She goes on to say it IS associated with constipation.
On page 62 of this document - she says exactly the opposite. Just 4 beats to the bar Laurie, please.
One of Dr Mischley's 5 treatments for PD is intranasal glutathione 200mg. I have been looking through iHerb and the only liquid glutathione I can find is liposomal. Will this be suitable for intranasal treatment?
It is a compounded prescription that has to be refrigerated.
Thankyou. Looks like it will be simply oral capsules.
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