The molecule cystamine, and its reduced form cysteamine, act via a number of pathways identified as being critical to the pathogenesis of PD. In particular, these agents are capable of crossing the blood-brain barrier, promoting the secretion of neurotrophic factors, the inhibition of oxidative stress, the reduction of inflammatory responses and importantly, have already been trialed in humans for a number of other clinical indications. In the last decade, compelling evidence has been accumulated that both cystamine and cysteamine can halt, and even reverse, ongoing neurodegenerative processes in a number of different models of PD, and as such, should now be taken forward to clinical trials in PD
Cysteamine as a novel disease-modifying c... - Cure Parkinson's
Cysteamine as a novel disease-modifying compound for Parkinson's disease: Over a decade of research supporting a clinical trial.
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Farooqji
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So, are they actually going to proceed to human trials? They say someone should, but I'm unclear as to whether they are actually doing it. Did I miss something?
This is quite a statement:
"Our laboratory has accumulated compelling evidence that both cystamine and cysteamine can halt, and even reverse, ongoing neurodegenerative processes in a number of different models of PD, and as such, should now be taken forward to clinical trials in PD"
"And importantly, have already been trialed in humans for a number of other clinical indications"
Cysteamine is already sold under the names of Cystagon and Procysbi (ER).
Both are used primarily for kidney disease, and in trial for Huntington disease..
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