Gut bacteria can EAT mediation

[koshca]

dailymail.co.uk/health/arti...

[beauxreflets]

Interesting article, thanks for sharing.

It certainly explains why Levodopa meds behave differently on a daily basis, and provides a clue towards the importance of having an extremely broad diet, while not consuming too much of any one particular food on a daily basis.

[Sane1]

Thanks for posting. Interesting following the research on the Brain/Gut connection. Hopeful that an approved alternative medication administration path is on the horizon.

[HeartSong in reply to Sane1]

Sane1, here in the U.S., I think there are trials in progress now for a continuous transdermal delivery system of levodopa that completely bypasses the G.I. system. Here's an article. michaeljfox.org/grant/allev...

[Juliegrace in reply to HeartSong]

Sadly, I believe Neuroderm has stalled out. They were bought by a large Japanese pharmaceutical company in 2017 and there was some talk that they (Neuroderm) had overstated the success of their initial trials.

[HeartSong in reply to Juliegrace]

Thanks for the update, Juliegrace. I knew that their progress had been interrupted because they were having problems with the original patch that they were using, but they supposedly ironed out that problem. I hadn't heard about the overstatement of their success. I wonder if it was due to an unintended consequence or if they knowingly did it with an intention of concealing the truth.

[Juliegrace in reply to HeartSong]

It seemed to be in response to people who felt the Japanese co overpaid for them. It could all just be rumors, too. I have been watching them in hopes that their insulin type pump would be fast tracked for approval but it seems unlikely at this point.

[Oceanflow]

Very interesting. Now if they could only tell us what we should NOT be eating so that our medication might be effective!

[b-erec]

I wonder why there is no injection form of L-dopa that could successfully bypass guts with unfriendly flora? Or there is some?

[Shaker33]

There is the duodopa pump. Also the new inhaled carbidopa/levadopa although it is used for off times between oral doses.

[felixned]

Just got a call from the Inbrija pharmacy- $500 for 12 day supply of inhaled ldopa. It goes from your lungs to the blood. I have serious worries regarding long term safety.

[HeartSong in reply to felixned]

Felixned, I, too, have serous worries regarding the long term safety of inhaled levodopa. It's using the delicate lung tissue in a way that it was never designed to be used.