Laurie Mischley says that PwP have high levels of fungus toxin which causes PD in mice!?

[JAS9]

Unscientific poll: Do you have a fungal infection?

I do on my left big toe. How can I best get rid of it?

Footnote: the fungus began approximately at the time I noticed my first PD symptoms.

("Footnote" - get it?)

---

youtu.be/GdksaTJ9y6I(Not working as expected?)

[Fed1000]

I can't translate. What kind of analysis do I have to do to understand that I have Fungine? How can I get rid of it?

[ion_ion]

I do have it. In 1996 I took latmisil and got cleared up. In 2006 it came back and kept under control with some creams. I have it only on the two smallest toes. The smallest one is hard to clear up but the other one get cleared but comes back. The creams or solutions are very expensive and they do a partially job. The current cream LUZU worked for a while but now does not seem to work anymore. I avoided latmisil now because is not good for the liver.

[parkie13]

Walter last, who writes and many health issues, his articles are very interesting, you can do a Google Search and come up with a bunch, says that ropey saliva is caused by a fungus. I know that some of us seem to be plagued by that. Again using 3% hydrogen peroxide by rinsing your mouth and gargling and spitting the ropey saliva really helps. You do have to do it all the time.

[Rhyothemis]

{ I have not been diagnosed with PD, so I don't belong in your statistics}

Weird - I have had for the past few weeks (maybe months at this point- I've lost track) a fungal infection. I think it is Malassezia. It started as 'jock itch'; it responded to miconazole, but came back every time I stopped using it (so I know this is not my usual vulvodynia symptoms - it feels a bit different, anyway). Then I ate a bunch of corn grits and it just exploded all over my body - especially my inner elbows. Green tea (topical and oral extracts) plus lots of miconazole have been keeping it under control and I am debating getting some oral ketonazole, but I might try garlic first (anything to avoid the dr's office). Perhaps not coincidentally, this all started after I had contact with a cat that has recalcitrant atopic dermatitis that flares up if she eats corn (corn in cat food - smh).

[edit: topical peppermint oil seems to help, also. Needs to be diluted.]

The weird thing is my really bad constipation came back about the same time - in fact it is worse than it has ever been.

I do wonder, though, if my autonomic problems are causing an impaired immune response or reduced skin barrier function and that's why I have a fungal infection.

~

If anyone out there has a good home remedy for fungal infections, please post.

{what hasn't worked - tea tree oil, zinc pyrithione soap, Bordeaux's Butt paste (balsam of peru)}

[Rhyothemis in reply to Rhyothemis]

Found an interesting bit of information - thiamine enhances growth of Malassezia in culture, and thiamine antivitamins have been investigated as potential antifungals:

ncbi.nlm.nih.gov/pubmed/266...

I've been taking thiamine for several months at varying doses ranging from 200 - 750 mg. I got my sweating on exertion back (prior to that I was barely sweating while exercising) and some other positives (e.g., more sensation in my toes) that might be attributable to thiamine plus a b-complex (thiamine-related information is mainly why I'm on this forum).

I'm feeling rather perplexed and discouraged at the moment...

~

A bit of potentially helpful information did come up in some searches of the literature - lysine might be a useful adjunct to antifungal treatments (trying to stay positive):

academic.oup.com/abbs/artic...

[aspergerian13 in reply to Rhyothemis]

Fungus: The Role of L-DOPA on Melanization and Mycelial Production in Malassezia Furfur.

ncbi.nlm.nih.gov/pmc/articl...

[Rhyothemis in reply to aspergerian13]

Interesting find.

[LAJ12345 in reply to Rhyothemis]

Are you in the US? Is it possible your corn is genetically modified? Try eating some organic corn and see if you get the same reaction. It could also be a reaction to glyphosate which is sprayed on corn to desiccate it when they harvest it.

[Rhyothemis in reply to LAJ12345]

It was organic corn - I try to buy organic whenever possible.

My theory is that there is something specific in corn that triggers the Malassezia to go from being a commensal to being pathogenic. Malassezia is closely related to corn smut and perhaps some strains 'remember' their corn smut ancestry a little too easily*. Yeast genes, like ours, can be epigenetically modified. So I suspect an epigenetic change was triggered that turned on some old genes. It seems almost impossible to eradicate Malassezia - the thing to do would be to find some way to get it to behave itself again, or maybe replace a bad strain with a with a better-behaved one.

Then there's also the fungal toxin (mycotoxin) contamination of corn to consider - for that aspect, organic/conventional would not matter as much as storage conditions and processing. Apparently, nixtamalization can greatly reduce mycotoxin levels, so tortillas, tamales and hominy are probably better choices as far as corn products go.

*Though it bears mentioning that all the commensal organisms in our microbiome can turn pathogenic - they just need the right (wrong?) conditions:

youtu.be/u8HU3JPtee8?t=1225(Not working as expected?)

[Rhyothemis in reply to Rhyothemis]

So I go check out PubMed, and what do I find - HDAC inhibitors (a type of epigenetic modifying drug) have been investigated as antifungals:

ncbi.nlm.nih.gov/pubmed/278...

[LAJ12345 in reply to Rhyothemis]

Interesting. In that case organic may be more prone to fungus as it isn’t treated.

[Rhyothemis in reply to LAJ12345]

I think that's true for Bt corn - mycotoxin production is reported to be reduced in Bt corn. I think there are some changes in levels of various mycotoxins in glyphosate resistant corn, but not sure of the overall effect. Though I definitely don't want glyphosate in my food. I am unsure about Bt modified crops since you can't wash away Bt if it is in the plant cells and Bt may affect the gut microbiome. There was one study in pigs that indicated that Bt modified corn-based feed did not change their microbiome, but that was a) in pigs and b) they only tested one type of Bt modified crop (the Bt mod is in a bunch of crops now, e.g., zucchini).

[parkie13 in reply to LAJ12345]

Yes yes yes it is a GMO corn, unless it's organic or popcorn it is

[Astra7]

Actually I had a very persistent toe fungus about the same time my PD possibly started. Had to have it lasered off in the end after trying everything else. Got it from a pedicure place which are apparently all filthy!!

[condor39]

Ask your pharmacist for some anti fungal cream, and apply twice a day, after washing and drying between the toes, Next try mixing some hydrocortisone cream with the anti-fungal cream.

If this doesn’t work see your doctor.

If the rash is very bad, get tested for diabetes

[PDGal4]

Wow, most interesting post. I stopped getting pedicures about 3-4 years ago because of what I assumed to be a fungal infection in my big toes. For as long as I can remember I’ve used fungal cream on my toes in the winter when feet are warm in shoes. It is not as much an issue in warm weather as I am mostly barefoot.

[2bats]

I fixed my fungal toes after several decades as a side benefit of going on a Keto Diet and latterly Carnivore Diet, low carb and zero carb, no meds.

The fungus runs on sugar, so no sugar => no fungus. Easy!

Best regards, Phil 2bats

[pad10 in reply to 2bats]

Your comment on the effect of sugar in your diet is interesting. I read a similar comment from someone who had seborrheic eczema of the scalp which is believed to be an overproduction of oil and an over growth of Malassezia, which is a type of fungus that’s found naturally in the skin’s oils. When he ate a lot of sugar it would also flare up. Apparently we all have fungus living on us - its the overgrowth that's the problem which it sounds like excess sugar contributes to.

[pad10]

I just spoke to a nurse friend of mine and the free clinic she works at recommends Vicks Vapor rub – just a light application (rub it in) on the area before bed time. also tea tree oil works and lastly Epson salts. She said al kill fungus.

[JAS9 in reply to pad10]

I'm trying tea tree oil first, but Vicks might be next.

[pad10 in reply to JAS9]

Good luck!

[LAJ12345]

My husband has had a bad fungal toenail for years way before Pd diagnosis. He was given an antifungal which made him very ill. Knowing what I do now I would say it was a reaction to the fungus being killed. Anyway he didn’t complete the dose and it has never gone away. He has been taking berberine and Allimed (high strength garlic) alternating with probiotics for his roseacea which seems to keep that under control. But the toenail is as bad as ever. End of last year he had an organic acids urine test and had high arabinose.

My daughter aged 15 had fungal toenail too. She tried laser, and all the home natural therapies but nothing worked . Finally she went to the dermatologist and has 3 months of a very strong antifungal drug whose name I can’t remember and it has gone and 2 years later has never come back. She used a uv light in her shoes every night too as if you don’t kill it in your shoes you will be reinfected. She had to have liver tests each month to check it was not harming her liver.

[Icequeen10]

i had toenail fungs for years. finally went to a cardiologist who diagnosed me with Raynauds ( lack of circulation ) he put me on a low dose vasodilator,, it took 2 years - my toes are great.