Trazodone for Parkinson’s: delays progres... - Cure Parkinson's

Cure Parkinson's

26,583 members27,900 posts

Trazodone for Parkinson’s: delays progression

5 Replies

Hi all, found this information about the benefits of Trazodone. It appears that new research shows that it can help slow progression.

scienceofparkinsons.com/201...

cureparkinsons.org.uk/news/...

cam.ac.uk/research/news/sci...

Read more about...
5 Replies
WinnieThePoo profile image
WinnieThePoo

Another click-bait title that doesn't really match the content. Simon, in the first link, explains trazadone is a candidate for drug repurposing trials based on some evidence in mice that it may slow neurodegeneration, but suggests it may not be a good PD candidate because it interferes with dopamine uptake.

sleezy profile image
sleezy

I would not take Trazadone because of its negative effect on motor function.

JohnPepper profile image
JohnPepper

I am always skeptical when I see the words CAN and POSSIBLY. If the product DOESdo something for Pd I a sure the articles would say DOES!

MBAnderson profile image
MBAnderson

Not quite.

Simon says, "The researchers concluded “that Trazodone may be effective in alleviating L-DOPA-induced dyskinesia and psychosis in Parkinson’s, but its deleterious effect on motor function is a concern and may limit its tolerability and usefulness in clinical settings”. and "In addition to these studies, there have been other case reports suggesting that Trazodone may actually cause Parkinson’s-like motor-related issues in the elderly."

Conclusion; "... but to date there has been limited investigations of it in models of Parkinson’s. The clinical data that we have available is mixed and suggestive that some caution is required..."

bamboo1953 profile image
bamboo1953

There are plenty of studies of medications, nutrients, vitamins, etc. that claim to show promise regarding some aspect of PD based on experiments conducted with mice. But as far as I know, only humans get diagnosed with PD, not mice! Best to take these studies with a grain of salt.

Not what you're looking for?

You may also like...

Benadryl in stead of Trazodone for sleeping

I was taking 150mg of Trazodone to get to sleep at night before I was on any PD medications. Once...

Serotonin

A couple of interesting links to evidence that serotonin may play play​ a more important role in PD...
partypants profile image

The science of Parkinsons. Easy to understand information about pd provided by scientists.

https://scienceofparkinsons.com/ Check it out. The latest blog is on The drugs – Dibenzoylmethane...
Hikoi profile image

Research Story Tip: Artificial Enzyme May Be First Step Toward Treatment for Parkinson’s Disease

https://www.hopkinsmedicine.org/news/newsroom/news-releases/research-story-tip-artificial-enzyme-may

Moderation team

See all
CPT_Aleksandra profile image
CPT_AleksandraAdministrator
CPT_Anaya profile image
CPT_AnayaAdministrator

Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.

Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.