Serotonin

[partypants]

A couple of interesting links to evidence that serotonin may play play​ a more important role in PD than otherwise thought.

BBC program​ about ecstasy​ and PD- youtu.be/FfP-cUTER5c(Not working as expected?)

Recent news on Trazodone​ - bbc.co.uk/news/health-39641123

[TheresaCurley]

I could not get to the end of this. I stopped around 11 minutes in. Could you summarize what the conclusion is of this news report.?

[partypants in reply to TheresaCurley]

It's about Tim Lawrence who was diagnosed with Parkinson's at 34. He's a former stuntman who had to give up work but he found that after taking Ecstacy he was able to do gymnastics again.

There are two researchers who study Tim and are interested in the action of serotonin in alleviating the symptoms of PD.

I may have missed some detail but I hope that sums it up.

[BUZZ1397 in reply to partypants]

So, substances that get one high help. That is actually not news.

[partypants in reply to BUZZ1397]

You seem to have missed the point. I'm not interested in short term alleviation of symptoms but want to understand if anyone gets any relief from the use of medication/drugs which stimulate serotonin. Got any experience of SSSRIs ?

[Coling]

Would you know what date this was screened?

[partypants in reply to Coling]

I think it was Feb 2001

bbc.co.uk/science/horizon/2...

[Coling in reply to partypants]

I wonder if any follow up research since then?

[mecklenberger]

It makes a lot of sense. Check the work of Dr Greg Willis and the Bronowski Institute.

[partypants in reply to mecklenberger]

No mention of serotonin that I can see.

[TheresaCurley]

Thank you.

[Serenity_finaly-1]

The Question, is will the powers that be, divide Parkinson's into dopamine dominate and serotonin dominate . They really need to look at the mental side of the issues.

[faridaro]

Very interesting video! Doesn't Azilect also boosts serotonin?

[partypants in reply to faridaro]

Not that I know - from Wikipedia,

Parkinson's disease is characterized by the death of cells that produce dopamine, a neurotransmitter. An enzyme called monoamine oxidase (MAO) breaks down neurotransmitters. MAO has two forms, MAO-A and MAO-B. MAO-B breaks down dopamine. Rasagiline prevents the breakdown of dopamine by irreversibly binding to MAO-B. Dopamine is therefore more available, somewhat compensating for the diminished quantities made in the brains of people with Parkinson's.[5]

Selegiline was the first selective MAO-B inhibitor.

[faridaro]

This is what I found on Rx List website :

5-hydroxytryptophan oral and rasagiline oral both increase affecting serotonin levels in the blood. Too much serotonin is a potentially life-threatening situation. Severe signs and symptoms include high blood pressure and increased heart rate that lead to shock.

[999---666]

you forgot main item, that they discovered another site called sub thalmic nucleus, a region or an organ that looks like two small beans.... anyway, it acts hyper in another movement disorder....can't recall name, but it's relatively rare.

I think...they said it was another site that produces dopamine. worth the mgs.

this fellow didn't benefit from dopamine that was presumably caused by estacy, but another neurotransmitter, glutamate they subsequently discovered, probably precursor of dopamine.

in other words its not the lack of production of dopamine neurotransmitter, that causes pd, it's other neurotransmitters, seretonin included.

[parkie13 in reply to 999---666]

They find plenty of dopamine even in advanced Parkinsons brains.

[999---666 in reply to parkie13]

dr mercola's sunday article likens sugar and fructose as behaviour modifiers just like hard drugs....... just skimmed over it, but it involves dopamine.

my father who was known for his robust health, always said sugar is for children.

[999---666 in reply to parkie13]

i'm coming across articles that state that dopamine is produced in several areas of the body........ !!!!!???

[999---666 in reply to 999---666]

I think that's not correct, according to this article. hang on, have to go get it.

scicurious.scientopia.org/2...

such a multi-task transmitter/hormone all in one location, seems counterintuitive.

[999---666]

tks smartypants....a ko article.