Parkinson’s breakthrough: Researchers fin... - Cure Parkinson's

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Parkinson’s breakthrough: Researchers find way to halt disease progression

JayPwP profile image
19 Replies

Unable to find any further information...

mcknights.com/news/clinical...

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JayPwP profile image
JayPwP
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19 Replies
jimcaster profile image
jimcaster

Unfortunately, the key words in the article are "in mice."

bassofspades profile image
bassofspades in reply tojimcaster

Those lucky mice!!

Xenos profile image
Xenos in reply tojimcaster

I wonder if mice use humans for testing their drugs...

JayPwP profile image
JayPwP in reply toXenos

Good one

MarionP profile image
MarionP in reply toXenos

Douglas Adams thought so.

berti2206 profile image
berti2206 in reply tojimcaster

ça commence toujours ainsi et c'est très prometteur

jimcaster profile image
jimcaster in reply toberti2206

Cela peut être encourageant, mais comme pour de nombreux autres essais sur souris réussis, je ne pense pas que je vivrai assez longtemps pour en bénéficier. J'espère que je me trompe.

berti2206 profile image
berti2206 in reply tojimcaster

mon épouse a 38 ans, a été diagnostiquée il y a 5 ans. J'éspère qu'elle bénéficiera des nouvelles technologies rapidement...

jimcaster profile image
jimcaster in reply toberti2206

Être diagnostiqué à 33 ans a dû être difficile. J'espère et je crois qu'une percée majeure viendra bientôt.

JayPwP profile image
JayPwP in reply tojimcaster

The post is hijacked :)

Will need Google translate

jimcaster profile image
jimcaster in reply toJayPwP

Sorry. I used Google translate to reply to Berti2206 in French simply because he originally replied in French.

JayPwP profile image
JayPwP in reply tojimcaster

No issues jim

park_bear profile image
park_bear

here:

nature.com/articles/s41598-...

"For efficient knock down, we designed and synthesized an amido-bridged nucleic acids (AmNA)-modified antisense oligonucleotide (ASO) that targeted SNCA with improved stability and cellular uptake in vivo. AmNA-ASO efficiently downregulated SNCA at both the mRNA and protein level in vitro and in vivo. Notably, AmNA-ASO was efficiently delivered into the mouse brain by intracerebroventricular injection without the aid of additional chemicals. Furthermore, administration of AmNA-ASO ameliorated neurological defects in PD model mice expressing human wild type SNCA. Taken together, these findings suggest that AmNA-ASO is a promising therapeutic strategy for SNCA-associated pathology in PD."

Possibly helpful but it is a long way from an animal model that tries to replicate Parkinson's to approval for human use.

Patrickk profile image
Patrickk

Bydureon, a repurposed Type 2 Diabetes drug is now in third-stage trials in UK for stopping Parkinson's in its tracks -- results expected 2023. Testing -- mice, open label, double blind -- has been going on for 10 years and it has been positive every time.

scienceofparkinsons.com/201...

bubee profile image
bubee

Ten years. Geez what on earth could take that long.

JayPwP profile image
JayPwP in reply tobubee

Missing intent

Xenos profile image
Xenos in reply tobubee

Vaccines...

Fredzu profile image
Fredzu

Crew

aspergerian profile image
aspergerian

The study:

Amido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides targeting α-synuclein as a novel therapy for Parkinson’s disease | 2020 pmc. Scientific Reports.

nature.com/articles/s41598-...

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