Interesting article mentioning taurine an... - Cure Parkinson's
Interesting article mentioning taurine and Parkinson's.
They mentioned that levodopa may deplete stores of taurine, great article.
Interesting comment here about restless legs
healthunlocked.com/rlsuk/po....
“I have had RLS for 5 years now and at it's worst I was getting spasms that locked both legs sticking straight out from my chair and vibrating.
One day last year I had one of my lateral thinking epiphanies and wondered if the Taurine that is added to Energy drinks to prevent the coffee jitters might help with RLS. upon purchasing some, very easily done since it is sold everywhere as a food supplement, being an Amino Acid, and trying it I found it had a very rapid effect and within 3 days I was down to a mild tingling in my toes that mostly clears up within 2 hours. The difference it has made to my quality of life is incredible and I cannot shout it loudly enough and feel a need to tell other sufferers to try it as I think RLS may be effected by amino acid levels, which is why taurine is an almost, there is more missing for a full cure.
I may have lucked into a fix that helps me, this doesn't mean it will help everyone but I am certain it will help some of you so please invest in a bottle of 1000mg Taurine tablets and try it for a month.”
Here’s a post below from a year ago by Greenday.
Interesting it can be made from methionine and cysteine but requires enough b6. But carbidopa destroys b6.
“Greendayin reply to Raphaekg
a year ago
Taurine is found in the nervous system and muscles, It is thought to help regulate heartbeat, maintain cell membranes, and affect the release of neurotransmitters in the brain. The body can make it out of vitamin B6 and the amino acids methionine and cysteine. PD patients show reduced levels of cysteine and/or deficient/insufficient levels of Vitamin B6. Imbalances in vitamins, minerals and amino acids can exacerbate and accelerate the progression of the disease.
A recent Human study verifies the link of reduced Taurine levels with the severity of motor and non-motor symptoms of Levodopa treated PD patients ncbi.nlm.nih.gov/pubmed/260...
*** Reduced plasma taurine level in Parkinson's disease: association with motor severity and levodopa treatment. ***
PURPOSE:
This study aimed to evaluate the level of taurine in plasma, and its association with the severity of motor and non-motor symptoms (NMS) and chronic levodopa treatment in Parkinson's disease (PD).
PATIENTS AND METHODS:
Plasma taurine level was measured in treated PD (tPD), untreated PD (ntPD) and control groups. Motor symptoms and NMS were assessed using the Unified Parkinson's Disease Rating Scale, the short form of the McGill Pain Questionnaire, the Hamilton Depression Scale, the Scale for Outcomes in Parkinson's disease for Autonomic Symptoms and the Pittsburgh Sleep Quality Index. Longtime exposure to levodopa was indicated by its approximate cumulative dosage.
RESULTS:
The plasma taurine levels of PD patients were decreased when compared with controls and negatively associated with motor severity but not NMS. Moreover, tPD patients exhibited lower levels of plasma taurine than ntPD patients. Interestingly, plasma taurine levels negatively correlated with cumulative levodopa dosage in tPD. After controlling for potential confounders, the association between taurine and levodopa remained significant.
CONCLUSION:
Our study supports that taurine may play important roles in the pathophysiology of PD and the disturbances caused by chronic levodopa administration.
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Lipid peroxidation is involved in neurological disorders including PD. A study on human red blood cells, show that Taurine significaly reduced the levels of lipid peroxidation.
“ Inhibition of lipid peroxidation, protein glycation and elevation of membrane ion pump activity by taurine in RBC exposed to high glucose.”
ncbi.nlm.nih.gov/pubmed/145...
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Besides the brain, PD may affect the peripheral system as well. Recent studies show that a-synuclein exerts prion-like behavior ncbi.nlm.nih.gov/pubmed/290... which allows it to propagate in the peripheral system effecting heart, muscles, eyes and other body organs. Taurine plays an important role as a basic factor for maintaining cellular integrity in the heart, muscle, retina, and throughout the CNS ncbi.nlm.nih.gov/pmc/articl... . One study compared taurine with coenzyme Q10 The results suggest that taurine is more effective for congestive heart failure ncbi.nlm.nih.gov/pubmed/153...
But the question remains how much taurine can reach the brain and replenish the deficient levels found in the”
I’ve also read the article, has anyone tried taurine for PD? If so, were the results favorable? And how so
Not very expensive – seems like it is well worth a try. Put some on order.
Park_bear
You seem to know what you’re talking about when it comes to meds and supplements, can I ask what’s your regimen? I want to start taking supplements especially HDT, but I don’t know 🤔 how to start or where to buy them. I am currently on C/L 25/100 CR 1 3x mirapax 0.25 1 3x and yesterday my neurologist added amantadine 100 1 3x the latter I am not too sure if I want to start it. Hopen to hear from you. 🙏🏽
Vita cost is a good supplier and they are offering a deal:
vitacost.com/vitacost-vitam...
As to dosage you can get it direct from the source here:
highdosethiamine.org/therap...
"In case of recent onset of the disease in patients whose weight is comprise between 50 to 65 kg (110 – 145 lbs), we begin the therapy with two grams of thiamine per day, before and after lunch. In case the patient weighs more, the dose can be three grams per day, always divided into two administrations. Oral thiamine should not be taken with juices or any sour beverage, water only. "
More about dosage here:
healthunlocked.com/parkinso...
Park_bear
So I went to vitacost site, do I start with 500mg or half? pardon my ignorance but I don’t understand when it say grams, is that in powder form? sorry for the confusión
500 mg = .5 g
healthunlocked.com/parkinso...
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Kind of odd that the article does not mention its most typical use - as an anti-glycation supplement (important for people with diabetes). I would have thought LEF would be all over that aspect, as AGEs (advanced glycation end products) are thought to be one of the major root causes of aging. It's also a supp that vegetarians and vegans might want to consider:
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