Injecting young donor plasma to treat conditions such as Alzheimer’s and Parkinson’s disease

[Farooqji]

“Injecting young donor plasma to treat or prevent aging, as well as conditions such as Alzheimer’s and Parkinson’s disease, has “no proven clinical benefits” like those advertised and is “potentially harmful,” FDA Commissioner Scott Gottlieb said in a statement.

advocator.ca/health/young-b...

[MBAnderson]

Thanks to you and Julie for shooting that down so quick.

[Kentson]

It is important to note that the FDA Commissioner would use the exact words "no proven clinical benefits" for HDT Thiamine B1 treatment. Exactly. I am not advocating donor plasma treatment, I am just stating that I in no way trust the phrase "no proven clinical benefits" from any individual involved in the US medical system.

[Rhyothemis]

From what I've read, this treatment has not shown benefits.

The injections are trying to mimic heterochronic parabiosis experiments - where a young mouse and an old mouse have their circulatory systems fused for a period of time. The old mouse winds up showing signs of rejuvenation, while the young mouse shows a few signs of accelerated aging.

There are both anti-aging factors in the young mouse's blood as well as pro-aging factors in the old mouse's blood which are diluted during parabiosis. The injections likely don't provide enough continued exposure to the anti-aging factors from young plasma and they do nothing to deal with circulating pro-aging factors (unless they include added antibodies or other means of neutralizing the pro-aging factors).

Some of the factors have been identified and there a number of groups working on therapies, but they are not ready for prime time (yet). They could be ready quite soon in some countries...

medicalxpress.com/news/2018...

newscientist.com/article/21...