Selegiline discontinued by manufacturer

[romit3]

My pharmacy has told me that Selegiline has been discontinued by the manufacturer. Is Rasagiline an equivalent?

[laglag]

This is what I found....Selegiline and rasagiline have been the only Food and Drug Administration (FDA)–approved MAO-BIs for the past 15 years. Both are relatively selective and irreversible, with some significant differences, mainly in their metabolites: amphetamine derivatives from selegiline and aminoindane from rasagiline.

Do you know who the mfg is?

[akgirlsrock in reply to laglag]

What do you mean by irreversible? My dr. Wants me to try rasagiline, but I don't like all the side effects listed, and I'm already taking Entacopone which has helped with cardopa/levadopa.

[laglag in reply to akgirlsrock]

That paragraph was copied from an article I was reading. I assumed irreversible meant you could not take both? I took rasagiline for about 4 or 5 years before I started C/L and didn't have side effects, but I know what you mean, there are some scary side effects.

[bassofspades in reply to laglag]

Irreversible means the mao that binds to the drug stays bound.

[Farooqji]

Jumex is still in the market

[JeanieBeanie in reply to Farooqji]

What is Jumex. Is it available in the Uk?

[Farooqji in reply to JeanieBeanie]

Don't know but it's manufactured by Sanofi Aventis

rosheta.com/upload/707315e2...

[laglag in reply to Farooqji]

Do you know anything about Mylan mfg? My C/L odt is on backorder until April 1st.

[JohnPepper]

I am not a chemist or a doctor. I believe that the two medications are similar. They are both MAOb inhibitors and as such, should do the same job. Rasagiline is the more recent medication and may be better.

[Joynb]

They are not the same, cousins more than siblings. Selegeline is available in Australia, marketed as eledpryl.

[grandmama16]

Interesting. My hubby has PD and was on Selegiline with C/L yet the med readout said they weren't to be taken together, and it could raise blood pressure. He had 2 blackouts and fell. He stopped taking it and has had no trouble since. I wonder if his Nuerologist even looked at the med readout. Probably just listened to the salesman. Should've stayed with first Drs. at the Univ. nuerology center but it's an hours drive. He's doing ok, tremors but not as bad as at the beginning tho he's having trouble with legs freezing. He's adverse to seeing any Dr. now.

[park_bear in reply to grandmama16]

The only interaction is selegiline enhances the effects of levodopa. That does not mean they should not be taken together. Please post a link to this alleged "med readout" if you have one.

Blackouts and falling are the result of low blood pressure, most likely orthostatic hypotension, a drop in blood pressure upon standing.

[grandmama16 in reply to park_bear]

I kept the Med. info readout in my purse to show pharmacists and now I can't find it. I'm sure the same info can be found on Web MD. Any pharmacy can print one out. These read outs are given everytime you get a pres. filled here. That's how I found out that Xanax and Norco shouldn't be taken together. When they say together, maybe they mean at the same time. Yes, it was generic as is his C/L Sinement. Anyway, good point about blood pressure. I just know the falling in that way...not remembering so a brief passing out...has stopped. He used to take his blood pressure reading on machine everytime we went to the store....not so much now. He doesn't take BP med. I take 2. I can't get him in for a check up. I think PD may be affecting his reasoning. I do give him B1 tho not a big amt., but he doesn't like taking vitamins in general. I found out that the B12 tab. we were taking was virtuously useless...liquid being better. For myself, Dr. told me to stop magnesium. Another waste of money. I hope the D3 she told me to take OTC is ok. She stopped the pres. D, 40,000 units a week. Thanks so much for your answer.

[akgirlsrock in reply to grandmama16]

Why is b12 liquid form better?

I was going to order tabs for under the tongue. Active B12 1000 | 60 Lozenges | 1000 mcg B12 as Adenosylcobalamin and Methylcobalamin | Seeking Health

Amazon's

Choice

for "seeking health b12"

Active B12 1000 | 60 Lozenges | 1000 mcg B12 as Adenosylcobalamin and Methylcobalamin | Seeking Health

Amazon's

Choice

for "seeking health b12"

[georgeypoo]

rasagiline is incredllbly expensive.....one really has to KNOW it works

[PDGal4 in reply to georgeypoo]

It is available in the US as a generic drug (for over a year or more, I believe). Much cheaper now.

[ParlePark in reply to PDGal4]

Rasagiline is generic for Azilect. When I was on it not too bad with insurance. Without insurance about 200$US a month.

[Autumn56]

I just refilled my husbands prescription for Segelilne a few days ago. Now they were capsules and not tablets.The Pharmacist did not mention that it was being discontinued. My husband does not have insurance and I found out you can get a GoodRX card or coupon that reduced the price for 60 capsules from about $76 to $45 at Walmart pharmacy . I just wish I had known it sooner.

[Cagey84]

Rasagiline and selegiline are inhibitors of an enzyme that breaks down levodopa. Rasagiline is the more modern molecule with a better side effect profile. There are indications but not clear proof that rasagiline may slow disease progression.

“Irreversible” refers to the way the enzyme is inhibited, it’s not a problem in the clinical sense.

In the UK, the NHS pays generic manufacturers £1.83 (about $2.50) for 28 tablets. Anyone over 60 or with a low income gets medicines free, everyone else pays £9.00 per prescription, no matter how much it costs the NHS.

Yes, I’m on rasagiline.

[bassofspades]

I just bought some selegiline so they still make it .it was $7

[Geenet]

I have been taking Rasagiline for nearly 3 years, since I first saw a neurologist on being diagnosed. I don't seem to be having any side effects and the neurologist said at my last appointment in November that he thought my PD was very slowly if at all progressing. As I am 80 years of age and live in the UK I don't have to pay for my prescriptions.

[Dehlia]

I’ve taken Rasagiline, $200/month, Walmart, for two years w/o any issues. I was taking c/l too but quit it. Didn’t like the side effects.

[Kecher in reply to Dehlia]

Dehlia---

What medications are you taking currently? Did you start out with Rasagiline?

[romit3]

Note that since I posted this I have in fact had no trouble getting my Selegiline on time.