According to the article I will link below, Selegiline is Neuroprotective. I have read some of the actual studies concluding this but the link is a good summary.
I have read that selegiline is not compatible with some cold medicines. I have not determined if this would apply to Ambroxol and Montelukast. Does anyone know? (Ambroxol and Montelukast are believed to protective as well. This can be elaborated upon in a different thread.)
Also, regarding the extensive dietary restrictions when taking Selegiline, can those who have taken it please share their experience? No chocolate? No coffee?
(And John Pepper, respectfully sir, this is about Selegiline. We know you stopped it and why. Thank you.)
cc, you can look up drug interactions on this website. I'm taking Lexapro so I shouldn't take Segeliline. You can put a lot of combinations in, even more than 2 and it lets you know if they will interact with each other and if it's a low, moderate or high risk.
If you go down to See Also, it tells you the Major drugs you shouldn't take with Segeliline. There are 124. Most of them I haven't heard of but none the less I think it's a good reference.
" When selegiline is taken at doses of 10 mg or less per day for the treatment of Parkinson's disease, there are no restrictions on food or beverages you eat or drink"
I had been taking resagilline for last three years- 1 mg per day. Now my neurologist has stopped it and has prescribed Pecitane (THP) 2 mg a day. Resagilline with Premipaxole never created any problem with me except some skin allergies.
I consider myself a Foodie and my doctor never suggested for any dietary restrictions. I eat whatever I like.
The doctors treating me are the Professors and head of Neurology department of top government medical colleges.
Yes, all suggest good level of physical mental exercise
Selegeline is a highly selective MAO-B inhibitor. No need for dietary restrictions. Symptomatic benefits with (the study by Lee's being a singular exception) no increase in mortality.
I was just discussing the need for selegeline with my MDS after taking it for 12 years with levodopa. Symptomatic benefits seem clear. I constantly get warnings from every new pharmacist who notes that I take selegeline with a low dose (subclinical, better-safe-than-sorry ) SNRI. Yeah, the pharmacists' guidelines state that this is contraindicated. When I remind them that selegeline is a highly selective MAO-B-inhibitor, they say "okay, no problem " So don't get scared off by supposedly contraindicated drug interactions or dietary restrictions. No worries here (other than having PD, global climate disaster, the lingering pandemic, and the Russia/Ukraine situation, of course.)
My husband has taken 10mg per day for 26 years and wouldn't go without it. He can tell if he has forgotten it. Never knew about the food exceptions. He doesn't suffer depression sometimes associated with PD. The trial Dr Lees did was flawed I understand because as PD is usually an older persons disease a lot on the trial were older anyway. My husband has been taking it since he was 45 and he is now 72.
The same 10 mg for all these years. Of course after 26 years his off times are worse. He has always been tremor dominant,hardly noticable when he is 'on', but bad when he is 'off'. I don't know if it has halted progression. He has had DBS. We go abroad 2/3 times a year until covid came. He does not get the depression associated with PD thankfully and I think this may be how silegiline helps. He thinks you should try it. First thing in the morning.
Yes but after 28 years you would expect that and he is 72. He had DBS in 2005. He had to come off the dopa agonist because it was causing compulsive behaviour . Our local health authority paid for it to be done at Frenchay hospital in Bristol. It is more common here now and he goes to Sheffield now for his checkups which is much closer to us. Our nurse tells us DBS is really good now. Much easier than when my husband had it done.
A lack of depression would tend, along with intact cognition, to suggest that he is one of the lucky relative few to have PD for several decades without material cognitive impairment. Well, maybe lucky is the wrong term but yknow.
It could be, though that drug has been around long enough now that if there was a pattern of it staving of PDD/LBD, we would likely know about it. Probably a genetic difference, I'd day.
ccraspberryExcept for the title of the article there seems to be nothing much to support selegiline being neuro protective. What is more this is research from last century, over 30 years old. In that time we haven't had any more evidence that Selegiline is neuro protective.
This is a 1999 article which gives a completely different picture
Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.
Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.
Why consider Ambroxol for PD?
Rasagiline or Selegiline?
Selegiline a new drug for me!
Interaction between supplements and selegiline 
