I am not a new person for this site but writing the first time. I am reading your posts for about four years and very grateful to everybody, because I have learned a lot of useful things from you, especially about dr. Constantini and thiamine hcl.
My husband was diagnosed Parkinson's disease in October 2014. He has tremor dominant Parkinson's disease. He has refused medicines used to treat Parkinson’s. During this time, various non-standard methods of treatment have been tried: acupuncture, electrostimulation, small doses of naltrexone, mannitol, CBD oil. No tangible positive changes. The disease continues to progress. Tremor and stiffness could be temporarily relieved by deep relaxation, but only at the time of the relaxation. Now he tries to work with thiamine, but has not yet found the right dose. Finally, three weeks ago he decided to go to a neurologist and tried to take sinemet. After the second dose, he has gotten diarrhea. He took sinemet for two weeks, the condition worsened. At the end of the second week Leonid stopped taking the medication. Now, three week later of the last intake of sinemet it's getting a little better. Do anybody has had a such side effect? If "yes" how to continue to take the sinemet?
Thank you very much for any responds.
Natalya.
Written by
nkurilskaya
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Sinemet is purely for symptomatic relief. Some people are not helped by it. Some doctors claim you have to try it for a long time to make a difference. My personal experience and that of some others is either it helps right away or it does not.
I would focus on the thiamine. For most Parkinson's symptoms it takes three or four months to have an effect. So take as much as he can tolerate and have patience.
Im guessing your husband is finding his symptoms getting more difficult to deal with and so that is why he decided totake sinemet. It is very well tolerated by most people but it can take a while to get used to it. He should talk to the neuro about what to do.
He could try Madopar which does the same as sinemet but is made by a different company.
He could try to reintroduce sinemet very very slowly and at a low dose.
Did he start any other treatment or increase dose of anything around the same time, like thiamine, that could be the cause rather than the sinemet?
Thanks a lot for your advice. Yes your guess is correct.
He suspended all other treatments while started to take sinemet. The dose was half of a 25/100 tablet 3 times a day. Nothing else. He will talk to neurologist about the Modopar.
Im fairly confident that he will tolerate sinemet or madopar (levadopa) with time. It takes alot of perserverance but it is the best medicine we have. All the others just enhance or make it work better. Good luck.
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