Gut and Parkinson: Here is the article... - Cure Parkinson's

Cure Parkinson's

25,550 members26,870 posts

Gut and Parkinson

JANVAN profile image
2 Replies

Here is the article, studie about the gut and Parkinson and some immunocomplexes

>>> unfortunately in german, but some of you will certainly able to translate it, I hope

(in fact that's also a question of me : which is a good tool to translate from internet ?)

univadis.de/viewarticle/ant...

Written by
JANVAN profile image
JANVAN
To view profiles and participate in discussions please or .
2 Replies
JANVAN profile image
JANVAN

O.K., and sorry, a bit to fast >>>> the reference at the end of the article is the original

article in english !! :-) :-)

lempa_nik profile image
lempa_nik

[Translation of JANVAN's German summary, which is slightly more digested than the original English abstract, though they contain much the same info. Now comes the usual question for a protective therapy: "Once the cows have left the barn (you've got the PD), can we bring them back (will the anti-infalmmatory drugs slow, stop, or reverse the disease) ?"]

Anti-inflammatory therapy for intestinal diseases apparently reduces the risk of Parkinson's

Key messages

Patients with inflammatory bowel disease are 28% more likely to develop Parkinson's disease. However, when the intestinal disease is treated with anti-tumor necrosis factor alfa (anti-TNFα), the risk for Parkinson's disease decreases and is even lower than that in the general population.

Background

Inflammatory processes are considered by some experts as a common denominator for both Crohn's disease and ulcerative colitis as well as for Parkinson's disease, which according to a new theory could take its course from the intestine. This assumption would be supported if a reduction in the inflammatory process with drugs lowers the likelihood of later Parkinson's disease - a hypothesis that is being reviewed in the current study.

Design

Retrospective cohort study based on data on the reimbursement claims of more than 170 million patients in the US for the period January 2000 to March 2016. Individuals without Parkinson's disease were selected with at least 2 claims for the diagnosis of inflammatory bowel disease and at least 6 months follow-up. The primary study goals were the incidence rates for individuals with and without inflammatory bowel disease with and without anti-TNFα therapy

Clinical significance

The study is another indication that Parkinson's disease has an early inflammatory component and could originate from the gut. The immediate impact on the practice is still low. Although the authors suggest that their findings provide the basis for better screening of patients with inflammatory bowel disease, not all experts are likely to consider the 28% relative risk increase to be adequate. Closer to this, another suggestion is to test the benefit of anti-TNFα therapy in individuals with a high risk of Parkinson's disease in a controlled trial.

You may also like...

gut brain connection and parkinsons

to correct the gut with probiotics etc or are there any studies been done on Parkinson's and this...

Solutions for gut microbiome of Parkinson?

https://scholars.uab.edu/display/hpayami \\"The study found an overabundance of opportunistic...

Gut-first theory of Parkinson's disease gains traction

response in Parkinson's....

Comprehensive coverage of gut health relevance and possible treatment for Parkinson

I found the article titled \\"Diet in Parkinson's Disease: Critical Role for the Microbiome\\" on...

Study finds overabundance of opportunistic pathogens in the guts of persons with Parkinson's

net/news/20200618/Study-finds-overabundance-of-opportunistic-pathogens-in-the-guts-of-persons-with-P