TH-17

[JANVAN]

Due to my worsening condition, I'm searching and searching the internet, and

now find this article. I hope the "chemicalists" under you, take an effort to read it and

search if they are further studies about that and how to "translate" , implement it in clinical praxis.........¨¨

arxiv.org/pdf/1403.3256.pdf

[GymBag]

Very difficult to read but you will love the ending.

Thanks Janvan

here lies hope

[Xenos in reply to GymBag]

The paper is not dated ?

[JANVAN in reply to Xenos]

Euhh, no, sorry.

But the same dokter has publiced an article in 2012 or 2013......, I try to find the link ...., but now I have to work....., I hope the stiffness goes a bit away.......not easy the last days,.,, although the last days the Wetter was/is nice >>> 25-27 Celcius and sunshine.....

[GymBag]

The Author changed his name to Wan-Jiung Hu but then I can not find subsequent work

[JANVAN in reply to GymBag]

I trie to search other information and perhaps Google : TH-17 and Parkinson

But yes, we have to be realistic, wenn it was such a breakthrough there would be more links, I think.....

[dadcor]

Can you imagine, so simple... just common NSAID's. May be it is worth to try ..??

[JANVAN in reply to dadcor]

Nah ja, he doesn't say just NSAID.....it's a bit more complex.

I'm just wondering and wondering why there isn't more Information about this.

But on a common German Website (unfortunately in German of course) they officially "classic medizin opinion" indicates now also a connection between gut and Parkinson and immuncomplexes......

[dadcor in reply to JANVAN]

No info because if it is about mainly NSAID's and yet a bit more complex may be.., it would be so cheap treatment... The "Big Pharma" would never allow it..

[jeeves19]

So auto-immunity usually is linked to gut issues/leakiness. Would this be the case with this or is autoimmunity against alpha-syn being driven from elsewhere? Also, if anybody could explain how NSAIDs combat this autoimmunity I'd be grateful. Thanks.

[DaveRochester in reply to jeeves19]

Me too

[park_bear]

Very interesting. The author has made a good case that Parkinson's is related to immune response. However he did not adequately demonstrate that the autoimmune response is to alpha-synuclein, because generation of alpha-synuclein is itself part of the immune response. So its presence only indicates an activated immune system. The fact that animals bred to lack alpha-synuclein are resistant to Parkinson's shows that alpha-synuclein is a key player but does not prove autoimmunity.

[Parkie-]

The link Janvan provided for us mentions that ‘’We should use anti-inflammatory agents such as NSAID to treat.’’

NSAIDs, Nonsteroidal Anti-Inflammatory Drugs, include Aspirin and Ibuprofen (Advil, Motrin).

About 8 years prior to my diagnosis, I had milder symptoms, which today I am told by the neurologist were ‘’pre-clinic’’ symptoms from PD. I didn’t know what it was at the time but I had noticed that Aspirin was helping me. My family doctor had told me to go on a low, daily dose of Aspirin and prescribed me Pantoloc to protect my stomach (was getting pain and reflux from Aspirin).

When I got diagnosed in 2017, I searched the Web and had found the following link which says : blog.pdf.org/2015/12/17/asp...

‘’a different study published in PLoS ONE (available here) found that aspirin might have potential for helping to stop PD. Can you tell us about the results? When we take aspirin, the body converts it into a compound called salicylate. In the new study, researchers found that salicylate was able to block the activity of an enzyme that has been indirectly linked to PD, called Glyceraldehyde 3-Phosphate Dehydrogenase, or GAPDH.’’

I definitely think that taking Aspirin all these years has postponed PD symptoms. I believe that my major symptoms would have appeared way faster if it had not been for Aspirin.

I thought I’d mention it.

[mistydog1 in reply to Parkie-]

I've found if I am having a particularly bad day I then take an aspirin as oppose to my regular medication . Usually within a 1/2 hour I am back on track. It makes sense that aspirin could help slow progression. People are prone to heart attacks are told to take a baby aspirin or specially formulated Bayer aspirin once a day. The aspirin helps stop platelets from sticking together causing a blockage. Aspirin will thin the blood maybe it's that same action which will stop the accumulation of protein in the brain cells.

[Parkie- in reply to mistydog1]

Yes, Aspirin thins the blood and in my case, I think it allowed a better vascularisation of tendons, reducing the sciatica and shoulder tendinosis I had at that time. According to Janvan's and my link above, it looks like it contains more to help PD.

[JANVAN]

precedings.nature.com/docum... yes no "following" (= subsequent ?) work I can't find (until now)......

[rebtar]

blog.pdf.org/2015/12/17/asp...