Citicoline, Aplha GPC

[rebtar]

Any experience or opinions on these? My functional medicine doc recommended phosphatidylcoline, but from what i've read, these are more bioavailable. Worth taking?

[parkie13]

I'm on my second bottle of citicoline. I take 300 mg three times a day with my sinemet CR 25/100. I think it is helping and augmenting the sinemet. I was going to say something at the end of my second bottle. I also take a half a tab of sinemet before going to bed. No citicoline then.

[Greenday in reply to parkie13]

How long have you been taking citicoline? please keep us updated, thank you for sharing.

[parkie13 in reply to Greenday]

Must be about a month and a half. I got a hundred and 20 capsule bottle, so three times a day would make it a 40-day bottle. I have not reduced my sinemet CR, I do think it stays longer with you and it augment it's efficacy.

[Greenday in reply to parkie13]

Thank you for your fast reply, according to the human study researchgate.net/publicatio... Citicoline showed levodopa saving effect. Patients who received half levodopa + citicoline showed more improvements. This study lasted 6 weeks.

[parkie13 in reply to Greenday]

Yes, I appreciated you posting the data, I read through it.

[Greenday in reply to parkie13]

I guess you've been already aware since you've been experimenting for over a month...

[Crystal04 in reply to parkie13]

Hi just wondered whether you're still taking choline and if so what sort of benefits you are getting?

[rebtar in reply to Crystal04]

I ended up taking phosphatydil choline as recommended by my doc. Reading through this again, I will stop after this bottle and try citicholine. I had forgotten about this thread.

[Crystal04 in reply to rebtar]

Hope you find it beneficial.

[parkie13 in reply to Crystal04]

I am still taking citicoline. However I'm taking is only once a day in the morning. The reason for that is I started getting headaches in the back of my head, that always seems to be the target area on me. When I first noticed the headaches I stopped taking citicoline is in experiment to see if that was doing it. I could see a smaller effect from Carbidopa levodopa, so I started again but just once a day. Seem to be doing okay on a once a day.

[Crystal04 in reply to parkie13]

Thanks for the update. I have just started taking it so I guess it's going to take a little while to see any benefit.

[parkie13]

If you do a search for citicoline there's couples threads that you can follow and get a whole bunch of information

[MWLE]

I started my father on Aplha GPC for his dementia about 4 weeks ago. He is not taking 900 mg x 2 times a day. My mother said that he did showed some improvements. I have also started him on Niacin 500 mg x 2 times a day but maybe too low of a dosage to see any effects.

[ryanJames1]

I started Citicoline about 12 months ago came off when I started having chest pains which can be a side effect for some

[Greenday in reply to ryanJames1]

which citicoline did you take and at what dosage? could you post the brand?

[ryanJames1 in reply to Greenday]

Harrow formula cdp choline I was only taking 250 milligrams

webmd.com/vitamins-suppleme...

[Greenday in reply to ryanJames1]

Thank you for sharing. I've been taking the same citicoline from Jarrows and I didn't experience any side effect.

[ryanJames1 in reply to Greenday]

Oh that s good been meaning to try again but maybe I'm just an unlucky one who does get the side effect

[parkie13 in reply to ryanJames1]

Didn't know that thanks

[ryanJames1 in reply to parkie13]

webmd.com/vitamins-suppleme...

[Greenday]

Multiple human studies suggest that Citicoline (CDP Choline) may benefit PD patients. The use of phosphatidylcholines as therapeutic agent for PD patients is inconclusive at best.

Citicoline studies have been posted multiple times in this forum.

Two of the main studies include the following:

1) Citicoline in the treatment of Parkinson's disease

researchgate.net/publicatio...

"Eighty-five (85) patients with an established diagnosis of primary Parkinson's disease were randomly assigned to receive their usual dose of levodopa (mean, 381 mg daily) plus 1,200 mg of citicoline daily or half their usual dose of levodopa (mean, 196 mg daily) plus the citicoline.

Results of the Webster Rating Scale, a pegboard test, drawing, writing, and walking tests, a test of emotional state, and an overall assessment, administered before and after four weeks of treatment, revealed no significant between-group differences.

* Improvements on the tests were shown by more patients who received half their levodopa dose plus citicoline than by those who continued to receive their usual levodopa dose plus the citicoline. *

It is concluded that the levodopa-saving effect of citicoline could be used to decrease the incidence of side effects and retard the loss of efficacy of levodopa in long-term treatment. "

2) Effect of citicoline adjuvant therapy on mild cognitive impairment in Parkinson’s disease

ijcem.com/files/ijcem001792...

To investigate the effect of citicoline adjuvant therapy on mild cognitive impairment (MCI) in Parkinson’s disease (PD) (PD-MCI) and its influence on plasma phospholipid (PL) levels in PD-MCI patients. The demographic data on 81 PD-MCI patients among 185 idiopathic PD patients who participated in the research from November 2012 to December 2014 were collected, and which were randomly divided into a citicoline treatment group and a control group.

Patients in the citicoline treatment group received citicoline sodium capsules orally (200 mg) three times daily (t.i.d.), in addition to the basic drug treatment. MoCA, SCOPA-COG evaluations and plasma PL level measurements were performed after 12 and 18 months of treatment.

The MoCA and SCOPA-COG scores showed a significant difference between the treatment and control groups after 12 and 18 months of treatment (P<0.05, P<0.01), and the plasma PL levels in the treatment group, compared to the control group, significantly decreased after 12 and 18 months of treatment (P<0.01, P<0.001).

* Citicoline adjuvant therapy might delay the cognitive function decline rate in PD-MCI patients and reduce their plasma PL levels. Suggesting that this treatment has probably neuroprotective effects. *

[rebtar in reply to Greenday]

Thanks

[rebtar]

Thanks