Parkinson’s disease tremors and serotonin

[Farooqji]

I came across a recent study on the subject which seemed interesting and worth looking into.

In their study Pasquini and colleagues found that the severity of rest tremor correlated with the loss of serotonin transporter in the brainstem raphe nuclei. The predominant serotonin deficiency in patients with prominent rest tremor may also explain why such tremors disappear during sleep and why they are often less responsive to levodopa than other cardinal features such as bradykinesia or rigidity. Based on the results of Pasquini et al., drugs that modulate the serotonergic system, such as eltoprazine, pimavanserin, nelotanserin, and SYN-120, should be investigated in the treatment of Parkinson’s tremors. The study report may be downloaded from below link

drive.google.com/file/d/196...

[Eliza-Jane]

Goodness! Where do you get all your information and find the time to research. I don't expect an answer, but I thank you from the bottom of my heart.

[TennesseeTim]

Pimavanserin virtually eliminated my father’s tremor (DLB patient). We were able to discontinue carbidopa levodopa. The one psychosis symptom that remained (though greatly diminished) after starting pimavanserin was hallucinations and they ended when we stopped carbidopa levodopa. I think dad must have been uniquely responsive to pimavanserin because the internet is not busting with other folks that have given up Sinemet after starting Nuplazid. Disclaimer: I became an ACADIA stock holder after I saw dad’s results.

[Farooqji in reply to TennesseeTim]

Thanks a lot for sharing your thoughts and father's experience