Parkinson’s disease managing reversible neurodegeneration- retracted!

[LAJ12345]

ncbi.nlm.nih.gov/pmc/articl...

This article by Marty Hintz etal was retracted because it didn’t follow proper protocol. I wonder if it is still relevant. It was interesting. I’m thinking of adding 5- HTP to try and increase seratonin.

Thoughts?

(Here is the retraction comment

Hinz M, Stein A, Cole T, McDougall B, Westaway M. Neuropsychiatr Dis Treat. 2016;12:763–775.

The Editor-in-chief and Publisher of Neuropsychiatric Disease and Treatment wish to retract the published article.

Following the conclusion of our investigation the decision has been made to retract the published article. The authors did not provide the requested IRB and informed consent information relating to this study and it was determined the study did not meet the ethical publication requirements for research involving human subjects. These requirements are based on guidelines issued by the World Medical Association and the International Committee of Medical Journal Editors. Additionally, the authors did not provide the study protocols, raw data and other study documents relating to this study as requested. Given our concerns about the standard of research ethics, competing interests and that the authors have not supplied the information we requested to verify and validate the reported findings, the editor has determined the article should be retracted.

Our decision-making was informed by our policy on publishing ethics and integrity and the COPE guidelines on retraction.

The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as “Retracted”.)

[Bolt_Upright]

That is an AMAZING article. I saved that to PDF before it disappears. If nothing else, it lays out all the details of things to deal with along with strategies. It could be tweaked. Thanks!

[LAJ12345 in reply to Bolt_Upright]

Yes I think I remember reading it ages ago but found it again when looking for 5-HTP

[Resano in reply to LAJ12345]

"Retracted" paint in red colour, what a nice stigma... If I am not wrong, the core of the issue by that time was a purported "conflict of interest", wasn't it ?

[LAJ12345 in reply to Resano]

Se the bottom part of my post, it states the retraction.

[LAJ12345]

This is my husbands genetic test. You can see what pathways are blocked by the dark cells. The pathway for seratonin and dopamine are both dis functional.

[Sampson7 in reply to LAJ12345]

LAJ12345 Where were you able to get this test? We did genetic testing and they only gave us a list of GRF that they tested that are known for PD, but would not give us the rest, sadly. Would love to know where you got this one from?

[LAJ12345 in reply to Sampson7]

it was opus 23. We had to go to a functional medicine doctor houseofhealth.co.nz/qualifi...

Sharon Erdrich had us do a 23andme and ancestry.com gene saliva test from their web pages, then she arranged for the files to be analysed by opus23 in the US. I’m not sure who she goes through.

I’m not sure if private individuals can go straight through opus23 as they want you to have genetic counselling by a trained practitioner just in case they find something disturbing.

I asked for the text files done by 23andme and ancestry.com so I have those, and there are a few free basic programs available so you can do yourself which show up common things like the mthfr genes or i just put them into an excel spreadsheet and if I see a gene snp I’m interested in a search for it to see which version he has.

[faridaro in reply to LAJ12345]

There is also a website mthfrsupport.com/ where you can download raw data from 23&me to get a report. It costs $30 and I've been using it for the past few years.

[LAJ12345 in reply to faridaro]

do they give you the full 23andme data file or just the SNPs for mthfr ?

[faridaro in reply to LAJ12345]

They give full variant reports

Here is the sample :

mthfrsupport.com/wp-content...

[LAJ12345 in reply to faridaro]

I asked for the full txt files and there are about 664,000 from ancestry.com and 638500 from 23and me obviously mostly overlapping.

The reports are handy to see the most common variants but as new information is discovered it is useful to have the raw data to search relevant SNPs too.

The opus report goes through the common variants also and explains the implications of each one and gives a list of what food and drugs and chemicals to avoid and which vitamins and herbals will be helpful. This is interesting as for my husband it says to avoid curcumin for example which was good to know that he shouldn’t have turmeric supplements. It recommended extra b1, b2,b3, and d.

I found the diagram of the chemical processes and where they were blocked very helpful.

[faridaro in reply to LAJ12345]

A few years ago I've done something similar through a medical practitioner who obtained a genetic functional report (37 pages) from NutriGenetic Research Institute with all kinds of supplement recommendations.

There is also Dr. Ben Lynch's website seekinghealth.com where anyone can download data from 23&me to get Strategene report which focuses on 9 metabolic pathways and gives nutritional and lifestyle recommendations, costs about $100.

[LAJ12345 in reply to faridaro]

I think I paid about $100 to each of ancestry.com and 23and me directly for their files, then for the functional doctor appointments (2 x 1 hour each ) and the opus report it was about $1000 from memory. NZ dollars.

At that point I think she was the only one in NZ with access to the opus reports but that might have changed since then. It was about 3 years ago. The ones you mention sound similar.

[Sampson7 in reply to faridaro]

thank you!

[LAJ12345 in reply to Sampson7]

see my answer to faridaro above

[faridaro in reply to Sampson7]

You are welcome, hope it helps. You may also want to check out Dr. Ben Lynch's website seekinghealth.com where anyone can order a genomic report with lifestyle recommendations for $95.

seekinghealth.com/products/...

[beehive23]

i tried hinz years ago ....no go.....balancing amino acids without constant supervision reslts in mixing your mucuna and l-tyrosine nac blah blah etc a dozen times a day and no real noticeable benefit for several years.......cheers

[LAJ12345 in reply to beehive23]

Thanks. I wonder how much difference in genetics makes to whether it is effective.Looking at his diagram even with added dopa and 5-htp his ddc is broken so they are likely to build up because they can’t be broken down fast enough. Which is probably why the l-dopa makes him feel over stimulated and anxious!

[beehive23 in reply to LAJ12345]

when i was involved with it the naturopath etc overseeing you recquied a 23 and me genetic workup for precisely that reason.....uptake discrepencies. there may be a mitochondrial connection as to the trash buildup / slow removal...pd alchemy ...alive and well....cheers

[JAS9 in reply to beehive23]

same experience

[Despe in reply to beehive23]

Actually, our homeopathic physician used Hinz protocol on his PD patients, but he told us that he no longer uses it as it's not effective, requires a lot of observation, etc.

[beehive23 in reply to Despe]

so ive heard and it wasnt effective for me ultimately.

[LAJ12345 in reply to beehive23]

Interesting.

[LAJ12345]

I’ve looked up drugs for insufficiencies in the DDC and came across this about antisense-oligonucleotide-treatment

drugtargetreview.com/news/6...

“By administering a one-time PTB antisense oligonucleotide therapy to mice, researchers observed an increase in neurons and elimination of Parkinson’s from the models.”

aadcnews.com/2019/01/10/stu...

[Despe in reply to LAJ12345]

I don't believe in mice trials any longer! Waiting for a real HUMAN trial!!

[Jana86]

Did anyone notice know many articles in the bibliography had also been retracted? Publisher of this article does not say who challenged it...seems like all of the articles labeled retracted (at least from their titles) seem to be looking at related issues involving the downside of L/C. Would love to know if they were all challenged by the same entity and who that is.

[LAJ12345 in reply to Jana86]

I’m always suspicious of this type of thing. Pressure from the pharmaceutical companies. Doesnt say that there was anything wrong with the conclusions, just that they didn’t follow protocol. I wouldn’t be writing off the study anyway.

[MN1066]

Before crediting too much value to the contributions of Marty Hinz I suggest searching the words "Quackwatch Mart Hinz"

[Resano in reply to MN1066]

If Dr Hinz' products and consultations were as cheap as those put forward by late Dr Costantini, I personnally would not care less about so-called conflicts of interest as long as the supporting science is acceptable.