Progression of PD is associated with gut dysbiosis

[aspergerian]

Progression

of Parkinson's disease is associated with gut dysbiosis: Two-year

follow-up study.

dx.plos.org/10.1371/journal...

[Hidden]

(gut flora)

Bifidobacteria are one of the major genera of bacteria that make up the colon flora in mammals. Some bifidobacteria are used as probiotics.

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As speculated in all sporadic diseases, PD is likely to be caused by an interaction between genetic and environmental factors. According to meta-analysis, prevalence of PD in 70- to 79-year-old population in Asia is significantly lower than those in North America, Europe, and Australia [49]. Similarly, prevalence of PD in all other age groups in Asia is low compared to other regions. Bifidobacterium is dominant in Asian people compared to Western people [50]. We showed that a low count of Bifidobacterium was associated with worsening of PD symptoms. Bifidobacterium may be protective against progression of PD. However, Bifidobacterium was not different between PD patients and controls in Japan [18] and the USA [15]. Additionally, Bifidobacterium was rather higher in PD patients than controls in Germany [12]. A small number of PD patients precluded us from drawing a decisive conclusion. Studies with a larger cohort for a longer time in multiple countries using the identical method for intestinal microbiota analysis [51] may elucidate the causal association of Bifidobacterium and other bacteria in the development and progression of PD.

Note: Bifidobacterium is listed in my daily (see my post) regimen. "1 x day Renew Life Ultimate Flora Adult 50+ Probiotic 30 Billion Supplement"

[jrg54321 in reply to Hidden]

Will you update your profile?

[Hidden in reply to jrg54321]

updated my Profile

[jrg54321 in reply to Hidden]

Thank you sir!

[jrg54321 in reply to Hidden]

The 50+ is twice as cheap as the enhanced on Amazon, and I can't see the difference. I may just go with that even though I'm 43.

[Hikoi]

Interesting reference

[faridaro]

Very interesting study. Speaking of intestinal a-synuclein - that's might be where mannitol is affecting its clumping. Just a thought...

[faridaro]

Also, want to add that I recently got on amazon "Fix your gut" book by John Brisson - just want to mention that I have no connection to the author or publishing of this book. Was very disappointed that there is no index and wouldn't even consider buying it if have known this beforehand, however the above drawback was more than enough compensated by the content of the book, even though had to write myself page numbers in its table of content

So what was so impressive? I've been hearing and reading so much about benefits of prebiotics, however it turns out that many of them also feed opportunistic bacteria along with beneficial ones. The only prebiotic this author recommends is Gallacto-oligosaccharide - GOS and also states that "Bifidobacteria seem to benefit greatly from GOS supplementation and increase more in number with it than any other prebiotic". As the source of GOS, he recommends supplement "Galactoimune" by Klaire Labs which I have not gotten yet, but considering to try.