Parkinson's and antioxidants. Interesting... - Cure Parkinson's
Parkinson's and antioxidants. Interesting article
Confirmation that both NAC and Israpadine are beneficial:
"Mitochondrial antioxidants and calcium modulators attenuate the toxic cascade in DJ-1 mutant dopaminergic neurons
We found that long-term treatment with either the mitochondrial-targeted antioxidant mito-TEMPO or NAC blunted the accumulation of oxidized dopamine and improved lysosomal GCase activity and proteolysis (Fig. 3, A to D). Furthermore, because increased Ca2+ entry through Cav1 channels enhances mitochondrial oxidant stress and dopamine synthesis (5, 18), we tested whether Cav1 channel antagonist isradipine (19) or the calcium-dependent serine/threonine phosphatase calcineurin inhibitor FK506 (20) could also regulate dopamine oxidation. Both isradipine and FK506 significantly diminished the accumulation of oxidized dopamine (Fig. 3E), highlighting the importance of Ca2+ in regulating dopamine oxidation in DJ-1 mutant neurons."
This work was done using an animal model.
Seems a very important finding1