MHC HLA autoimmunity inflammation in PD - bibliography

[aspergerian]

Here is a miscellany of references relevant to Sulzer et al 2017,

who did not claim that autoimmunity is the only causal factor in PD.

Indeed, anti-alpha-synuclein may be an etiologically significant

co-factor in only a subset of PwP.

alzforum.org/news/research-...

All but one is open access. Be forewarned, mmunology has its own

lingo.

Inflammation and Adaptive Immunity in PD.

ncbi.nlm.nih.gov/pmc/articl...

The Role of Innate and Adaptive Immunity in PD.

ncbi.nlm.nih.gov/pmc/articl...

MHC-I expression renders catecholaminergic neurons susceptible to

T-cell-mediated degeneration.

nature.com/articles/ncomms4633

PD-associated genetic variation is linked to quantitative expression

of inflammatory genes.

ncbi.nlm.nih.gov/pubmed/284...

Common Genetic Variant Association with Altered HLA Expression,

Synergy with Pyrethroid Exposure, and Risk for PD: An Observational

and Case-Control Study.

ncbi.nlm.nih.gov/pubmed/271...

Age and duration of inflammatory environment differentially affect

the neuroimmune response and catecholaminergic neurons in the

midbrain and brainstem.

ncbi.nlm.nih.gov/pubmed/243...

Role of cytokines in inflammatory process in Parkinson's disease.

ncbi.nlm.nih.gov/pubmed/170...

Distribution of major histocompatibility complex class II-positive

microglia and cytokine profile of Parkinson's disease brains.

ncbi.nlm.nih.gov/pubmed/145...

Association of Parkinson disease with structural and regulatory

variants in the HLA region.

ncbi.nlm.nih.gov/pubmed/241...

[Catlou]

And in layman's terms .

[aspergerian in reply to Catlou]

Tere is substantial research looking at immune system atypicalities that may be related to PD.

Clinical correlation of peripheral CD4+‑cell sub‑sets, their imbalance and Parkinson's disease.

spandidos-publications.com/...

Clinical characteristics and peripheral T cell subsets in Parkinson's disease patients with constipation.

ncbi.nlm.nih.gov/pmc/articl...

[jeffreyn in reply to Catlou]

Laymen come in all shapes and sizes, but I think that a lot of laymen would appreciate this recent post on "The Science of Parkinson's disease" blog.

It is written in the usual folky SOPD style, and contains a number of helpful diagrams.

The post is quite long, but you wouldn't need to read all of it, to get a lot out of it.

scienceofparkinsons.com/201...

[Hikoi in reply to jeffreyn]

Great site, thankyou. Hope others bookmark or save a link. So many topics covered.

[aspergerian]

Jeffrey,

An excellent delineation. Thank you for sharing it.