Theracumin verses longvida curcumin

[zawy]

Dr Trutt seems to have changed his mind about longvida being the best curcumin.

truttmd.com/curcumin-update...

I found some problems with his discussion and posted a comment to that page:

Dr Trutt, the chart you got from youtube is from a Japanese study that was funded by the Japanese Theracumin company. Prior to their measurement of "curcumin", they used "1000 U beta-glucuronidase at 37 C for 1 hr to hydrolyze the curcumin conjugates" which sounds like they did not measure free curcumin. This correlates with your previous comments questioning a previous study's BCM-95's "free curcumin" data, since this study found a lot of "curcumin" in BCM-95. They never mention free curcumin or the conjugates in plasma.

The data are based on curcumin in the pills and BCM-95 has 17 times more per pill, so even Theracumin's paid researchers showing 10x better theracumin absorption are admitting BCM-95 per pill is 70% better. Theracumin is charging 30x more per curcumin, so at 10x better theracumin absorption per curcumin, BCM is still 3x less expensive per effectiveness. So, BCM-95 is 3x less expensive and you can take 3.5 pills instead of 6 to get the same effect.

Again, this does not seem to mean "free curcumin". But there seems to be only 1 study on longvida free curcumin, and I can't get the entire artilce

An indian study looked at their own formulation of 6% curcumin: "lipidic formulation of CRM (CRM-LF). CRM-LF consisted of CRM (6.17% w/w), Gelucire44/14 (16.46% w/w), Labrasol (5.76% w/w), Vitamin E TPGS (3.29% w/w), PEG 400 (55.55% w/w), ethanol (8.23% w/w), anhydrous citric acid (2.88% w/w) and HPMC E5 (1.64% w/w). CRM-LF forms the nanosized globules upon dilution with aqueous medium."

They got 1.3 uM/L free curcumin max when converted to a 2 g dose. They patented it and published in 2012 titled "Bioavailability of a Lipidic Formulation of Curcumin in Healthy Human Volunteers"

They did not have controls, so the complaint you made about BCM-95 might also be made here.

What do you think about people trying to mix turmeric or curcumin in a ultrasonic denture cleaner with heated lecithin to try to get a similar formulation?

[mktbob55]

I thought people on this site spoke English? I want to understand the concept as i take tumeric and pepper. However I don't want to go to school to understand this post

[zawy in reply to mktbob55]

Summary: there is no evidence any form of curcumin gets to the human brain.

[mktbob55 in reply to zawy]

Thanks

[LouThomas in reply to zawy]

As of August, 2017, there is evidence that Longvida curcumin gets to the brain. Amyloid proteins in the brain can be directly viewed through the eye on the retina, and they were observed to become infused with curcumin after treatment with Longvida curcumin.

"Curcumin labeled the central dense Aβ core intensely and, to a lesser degree, the radiating fibril arms"

ncbi.nlm.nih.gov/pmc/articl...

[zawy in reply to LouThomas]

The authors were funded by Longvida. They only say it increased in the retinas of humans. The brain images were stains performed on cadavers or rodents, so there's no indication that it crossed the blood-brain barrier, except that they claim it got into the retina which also has a barrier. But the way they "measured" it in the retina is highly suspect. It involved a lot of data manipulation and they say the "RAI" which determined the intensity is a trade secret. They do not say how the RAI is related to the presence of curcumin in the retina. The human dose was 4 grams per day.

[LouThomas in reply to zawy]

"FUNDING. National Institute on Aging award (AG044897) and The Saban and The Marciano Family Foundations." So, not funded by Longvida. But, it *is* true that two of the study authors are also founders of Longvida, as revealed in the conflict statement:

"Conflict of interest: Y. Koronyo, K.L. Black, S.R. Verdooner, and M. Koronyo-Hamaoui are founding members of NeuroVision Imaging. S. Frautschy and G.M. Cole are founding members of Optimized Curcumin Longvida."

[Farooqji]

black pepper mixed with turmeric is as effective as Longvida curcumin

[MBAnderson]

Zawy, have you seen these recent posts and what do you think??

sciencedirect.com/science/a...

healthunlocked.com/ataxia-u....