Serrapeptase, technically called Serratio Peptidase, is a proteolytic enzyme, which means that it chops up or digests protein. It is produced by bacteria in the gut of silkworms and is used to digest their cocoons. When this enzyme is isolated and coated in the form of a tablet, it has been shown to act as an anti-inflammatory and a pain-blocker, much like aspirin, ibuprofen and other nonsteroidal anti-inflammatory drugs (NSAIDs). What’s more, preliminary research indicates that Serrapeptase may even help inhibit plaque build-up in arteries, thereby preventing atherosclerosis (hardening of the arteries) and a resulting heart attack or stroke. Therefore, much like aspirin, this naturally derived enzyme may work to prevent inflammation, pain, heart attack and stroke. Unlike aspirin and other over-the-counter (OTC) NSAIDs, Serrapeptase has not been shown to cause ulcers and stomach bleeding.
Serrapeptase is thought to work in three ways:
It may reduce inflammation by thinning the fluids formed from injury, and facilitating the fluid’s drainage. This in turn, also speeds tissue repair.
It may help alleviate pain by inhibiting the release of pain-inducing amines called bradykinin.
It may enhance cardiovascular health by breaking down the protein by-products of blood coagulation called fibrin. Conveniently, Serrapeptase is able to dissolve the fibrin and other dead or damaged tissue without harming living tissue. This could enable the dissolution of atherosclerotic plaques without causing any harm to the inside of the arteries.
Serrapeptase has been used in Europe and Asia for over 25 years. Because the enzyme digests or dissolves all nonliving tissue, including blood clots, cysts and arterial plaque, it is used to treat a variety of conditions, including sprains and torn ligaments, postoperative swelling, venous thrombosis (clots in the legs), ear, nose and throat infections and atherosclerosis.
Serrapeptase is perhaps one of the world’s most exciting enzymes being studied in regard to its wide variety of clinical applications. Currently, especially in Europe and Asia, it is clinically used for many, many negative health conditions. One of the most well-known proponents for this enzyme was the German physician, Dr. Hans Nieper. He had great success supplementing with serrapeptase to promote normal heart and circulatory system health.
This Youtube will give more information, its by John Gray, Ph.D
Thank you Vjessv for bringing this nutrient to our attention. I did a quick search on this enzyme and found reference to it possibly breaking down Amyloid Plaque which has been implicated in both Parkinson's and Alzheimer's. Curcumin is supposed to have similar properties.
This nutrient will help with systemic pain, fatigue, internal inflammation that most PwP suffer with, it is much safer to use than non-steroidal anti-inflammatory drugs (NSAIDs),
also it helps the gut immensely with digestion.
Dopamine is made from the AA tyrosine. Eating a high protein diet promotes dopamine production. It is abundant in poultry, meat, dairy products, almonds and avocados.
So why is it that if you are a PwP eating these food produce it doesn't raise dopamine?
Is it because the gut/brain connection been compromised?
Is it that gut can not absorb the vitamins, minerals, nutrients, Proteins and so forth that the body needs to function properly?
We have two brains and the Second Brain is in the gut.
They Call Serrapeptase 'The miracle Enzyme.
I am not saying this is a Cure, the first youtube video says it all..
Serrapeptase is not a nutrient it's a enzyme different ball park that a side, It's a bit of a stretch to say Dopamine is made from Tyrosine. Tyrosine is transformed into L-DOPA by the enzyme tyrosine hydroxylase. It's the rate of the transformation of by tyrosine hydroxylase which is the limiting factor . L-DOPA is the molecule before dopamine in parkinsons L-DOPA known as the drug a levedopa as a pill L-DOPA goes into your brain. L-DOPA is changed into dopamine via an enzyme known as aromatic amino acid decarboxylase (AADC), and then you have dopamine, ready to be stored and released as either a neurotransmitter or a hormone. But not every cell in the brain has dopamine, and in fact dopamine is produced only in a few, very specific regions of the brain they are Substantia Nigra and the Ventral Tegmental Area . So in the case of Sinimet the Carbidopa is essential to forming a complex with L-DOPA to carry it into the brain preventing it to be broken down before reaching it's target. High protein intake interferes with formation of Carbidopa forming the complex.
Hi Norton, I was wondering if you have any links or info regarding Serrapeptase and amyloid plaque? My Dad has recently been diagnosed with Amyloidosis and he has tumours in his lungs and chest wall. He is taking EGCG, Curcumin and Serrapeptase after I did some research but didn't find much evidence for Serrapeptase and amyloid plaque. I am convinced myself because there isn't much Serrapeptase doesn't seem to help with but I need to convince my Dad's drs or at least have something to show it might help reduce his tumours. The Dr's are questioning if he can take these supplements so I am desperate to find more supporting evidence. Any help here is much appreciated, thanks Louise.
So there is a gut/brain connection....
i would love to found out what this means exactly
Substantial production of dopamine in the human gastrointestinal tract.
J Clin Endocrinol Metab. 1997 Nov;82(11):3864-71.
Eisenhofer G1, Aneman A, Friberg P, Hooper D, Fåndriks L, Lonroth H, Hunyady B, Mezey E.
Author information
1Clinical Neuroscience Branch, National Institute of Neurological Disorders and Stroke, National Institute of Health, Bethesda, Maryland 20892-1424, USA. ge@box-g.nih.gov
Abstract
Considerable urinary excretion of dopamine metabolites indicates that large amounts of dopamine are produced in unknown locations of the body. This study assessed the contribution of mesenteric organs (gastrointestinal tract, spleen, and pancreas) to the total body production of dopamine in humans and examined the presence of the rate-limiting enzyme for dopamine synthesis, tyrosine hydroxylase, in gastrointestinal tissues. Blood sampled from an artery and portal and hepatic veins in eight subjects and from arterial and renal venous sites in other subjects was analyzed for plasma concentrations of dopamine and its metabolites. The activity and distribution of tyrosine hydroxylase was also examined in tissue samples from the stomach and duodenum. Higher concentrations of dopamine and its metabolites in portal venous than arterial plasma indicated substantial production of dopamine by mesenteric organs (12.0 nmol/min) amounting to 42-46% of the renal removal of circulating dopamine metabolites. Tissue samples showed immunoreactive tyrosine hydroxylase in non neuronal cell bodies and detectable levels of tyrosine hydroxylase in non neuronal cell bodies and detectable levels of tyrosine hydroxylase enzyme activity. The results show that mesenteric organs produce close to half of the dopamine formed in the body, most of which is unlikely to be derived from sympathetic nerves but may reflect production in a novel non neuronal dopaminergic system.
PMID: 9360553 [PubMed - indexed for MEDLINE]
Substantial production of dopamine in the human gastrointestinal tract,
Gut/brain Connection compromised (Low Level Systemic Inflammation), after many years the brain is slowly depraved of dopamine?
Maybe i'm clutching at straws...
• in reply to
This gut/brain thing seems to keep cropping up with PD. It is very interesting.
The anti-inflammatory properties of Serrapeptase and as mentioned Curcumin having similar properties. I tried Curcumin but after using it for about three weeks, I had excrutiating abdominal and pain in the left side which calmed down and stopped after three days of not taking it.
I got the impression that Curcumin actually caused this Inflammation.
As a test I restarted taking it for a few days, but quickly noted the return of the discomfort.
Vjessv. Just looking again at the tags on your original post to this thread, I can see several possible health connections that some PwP may also have, which may or may not be directly attributable to Parkinson's. Therefore, by bringing Serrapeptase to our attention you may well have widened our knowledge for which I personally am thankful for!
I'm sorry, i should have put in the heading that this thread was about Pain management,
serrapeptase works as an anti inflammatory, if you have problems with joints, headaches,
or movement of any kind it will help,it cleans the body of junk in the blood stream so if you have arthritis it helps clean the joints, you can buy serrapeptase on amazon, iherb, holland and barratt in the u.k,
Well, well, Osidge, that has rather levelled the playing field. In today's society it seems that there are people who make over exaggerated claims about many things and that includes pharmaceutical medications as well.
Even so, I will continue to do my own research on Serrapeptase, but will look at the references and claims with an even more critical eye than I have done up to now.
Serrapeptase seems to be safe for adults when taken by mouth, short-term (up to 4 weeks). The long-term safety of serrapeptase is not known.
Special Precautions & Warnings:
Pregnancy and breast-feeding: Not enough is known about the use of serrapeptase during pregnancy and breast-feeding. Stay on the safe side and avoid use.
Bleeding disorders: Serrapeptase might interfere with blood clotting, so some researchers worry that it might make bleeding disorders worse. If you have a bleeding disorder, check with your healthcare provider before using serrapeptase.
Surgery: Serrapeptase might interfere with blood clotting. There is a concern that it might increase bleeding during and after surgery. Stop using serrapeptase at least 2 weeks before a scheduled surgery.
I used serrapeptase to get rid of fibroids. I was diagnosed with orange sized fibroids and scheduled for surgery. I had to wait 6 months and during that time I took 120UI twice a day of Enerex brand. When I went for my surgery, the fibroids were completely gone. That's pretty amazing. I don't find I get any real pain relief from serrapeptase. I use HempWorx cbd oil for pain. It's helped a lot. I had heard CBD can be very good for controlling seizures and parkinson's. You can get a pure organic strain at hempworx.global. Our dog is on it for her pain and doing great too.
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Vitamin C + Omega 3 Fish Oil Combo 
More pieces to the puzzle about getting a more stable supply of levodopa to the brain
The disease is in thought, environment, perception and inherited information. Then it goes into our body chemistry.
