CMT1A

[minkymae]

My mum has cmt type 1a as do most of her family. The disease is dominant. I do not as far as I know have it but my GP thinks my daughter has it. Is this possible?? Could I be a carrier of the gene without any symptoms or would I need to have it for her to have it??

[CMTUnitedKindom Partner]

You would have to have the gene in order to pass it on. It's not possible to be only a carrier of type 1a. But it is possible to have the gene and have no symptoms, or so mild that you don't even know!

If you'd like to know for definite, I suggest you ask your GP to arrange a blood test for confirmation. If you don't have it then, your daughter can't have it!

Karen

[Ladywonder in reply to CMTUnitedKindom]

I was told it could skip my children but grandchildren could get it etc that it can lay dormant in one family show up in the next I just pray it stays away from my children but worry constantly that it's showing up in subtle ways now.

[Amanita in reply to Ladywonder]

Hi, Ladywonder, CMT 1A does not skip generations. As KarenCMT says, it may be so mild as not to cause any problems, but if your child has the gene, his/her children each have a 50% chance of inheriting it. If your child has not got the faulty gene, then it cannot be inherited by his/her offspring.

[KarenNic]

Hi Karen/Minky

I had a full genetic map done the year before last and was told I had CMT1A - the geneticist and I talked through this in detail and although my daughter does not have symptoms and her brothers do, there was still a 50% chance that she was a carrier as it is carried on the X chromosome.

Karen