Dr. Eric Topol: post: The First Diagnostic Immunone

[msnik]

erictopol.substack.com/p/th...

The First Diagnostic Immunome

A Big Step Forward By Sequencing B and T Cell Receptors Plus A.I.

Eric Topol

Feb 22, 2025

"B and T lymphocytes contain a treasure chest of information about our immune response to pathogens, vaccination, environmental exposures, and untoward, self-directed attack (to our organs, tissues, and cells). The B and T cell receptors are like antennas, extending outside the cell (Figure below), that act as the sensors to mount a response to these different antigens. Their response is stored, but these receptors are exceedingly complex to decode because their diversity is extreme, with extensive gene rearrangements and somatic mutations. Until now, sequencing these receptors has not been used to diagnose an autoimmune condition or exposure to a pathogen. Their only clinical use case to date has been quite rare, in certain lymphomas for diagnosis and management."

I do not pretend to understand most of this, but, I thought that it was interesting and important enough to share, esp. for those of you who are more expert. I think we are living in very interesting times.

[Bornagain514]

Eric, Thanks for the post explaining one of the functions of our B and T cells. The antenna idea gave me the best visual for understanding CLL. I too have high hopes and prayers that AI will unlock some real knowledge and hopefully lead to a cure of CLL. Blessings to you and be well!

Elizabeth

[msnik in reply to Bornagain514]

hello,

thanks for your reply, but just to clarify, Dr. Eric Topol is the author of the substack....I just posted the link to it....

thanks for the blessings....we are lucky to have so many brilliant scientists working on behalf of all of us. msnik