I started Paxlovid again.

[RSilver]

I tested positive again and started Paxlovid the next day. I can't find much written about repeating Paxlovid 3 months later when reinfected.

Recap: I tested positive in July, started Paxlovid, had a rebound on day 9, and got a second prescription for it.

Here I am 3 months later, which in Canada is the recommended time interval for immunocompromised individuals to get a booster, and I am infected again. A week before getting my bivalent booster.

I wear a mask any time I am indoors and outside if people are too close. This is so frustrating.

Has anyone seen information on repeatedly taking Paxlovid?

[SofiaDeo]

I doubt there is much published. Paxlovid is so new, and the conditions of needing it because of repeat infection, aren't super common.

[RSilver in reply to SofiaDeo]

Thanks. I do hope that the effectiveness does not diminish with repeated usage.

[SofiaDeo in reply to RSilver]

I think if it ceases to be effective, it's because the Covid variant has developed resistance. If you are successfully clearing the virus in between infections, the risk of Paxlovid resistance is minimal. I would think, if someone tested positive for months on end, and kept intermittently repeating Paxlovid treatment,that would be more likely to contribute to any resistance.

[bennevisplace]

It's possible that in the space of 3 months you have caught two different subvariants of Omicron, which has been throwing off mutations each one with some resistance to antibodies from previous subvariants. Some of these have a known country of origin, others not.

Watch out for Omicron BA.4.6 which now accounts for 14 % of documented new cases in the US (a week ago it was reported as 12%).

Very useful source of Covid stats in Canada:

health-infobase.canada.ca/c...

[RSilver in reply to bennevisplace]

I think you are very possibly correct. I was actually looking forward to the bivalent booster.

Health Canada announced Friday it has approved the updated shot, which has been designed to target Omicron’s BA.4 and BA.5 subvariants that are the dominant strains circulating in the nation at the moment.

[bennevisplace in reply to RSilver]

Good to know the latest bivalent vaccines will be in use by the time you have yours. Best wishes for a swift recovery!

[RSilver in reply to bennevisplace]

Thank you.

Stay safe and stay healthy.

[Davidcara]

do you have covid symptoms?

[RSilver in reply to Davidcara]

Yes. Mine were blocked sinuses, weakness, chills, fever.

I typically do a rapid test at the first sign or symptom. The rapid tests are free here so I think most people have a couple of boxes. There is no charge for Paxlovid. A phone call to my specialist was required to have him fax a prescription to the pharmacy. That took about 90 minutes.

Would that process be similar where you are?

[Davidcara in reply to RSilver]

where I am at in California, you get symptoms you either say it is a cold, or if you are a reasonable responsible person you rapid or PCR test. If you are high risk, you call your medical provider in hopes of getting paxlovid or bebtelovimab. If you have medical insurance you probably can get the meds if you are immune suppressed, have significant co-morbidities, or above 65 years old. If not, you hope for the best, and if you are vaccinated you probably do ok.

Good Luck, hope you get what you need.

[RSilver in reply to Davidcara]

Yes. Thanks.

Today is day 4 of Covid, day 3 of Paxlovid. My first negative test today but still feeling weak .