TP53 Wild Type.

[westcountrylad]

Although I have learnt much about my CLL since 2008 and CD markers,fish tests etc, I have yet to get a more fuller understanding of the above. Any better minded boffins on here want to share any knowledge. I just like learning about blood cells and genetics.

[Newdawn Administrator]

This past post courtesy of Jm954 is a good start to aid understanding of TP53.

What is TP53?

‘The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumour suppressor, which means that it regulates cell division by keeping cells from growing and dividing (proliferating) too fast or in an uncontrolled way.

You should have two copies and if this is mutated or partially deleted del(17p), it causes loss of one copy of the tumor suppressor TP53, which then cannot fulfilled its important role in DNA repair, cell-cycle arrest, and apoptosis (cell death). The lack of apoptosis causes the cells to live much longer, even if they have DNA mutations which should induce apoptosis.

CLL expressing a mutated TP53 or del 17p generally does not respond well to chemotherapy and a targeted treatment is advised if available.’

Newdawn

[westcountrylad in reply to Newdawn]

Thank you for this, I understand a little more now which was like switching on a light bulb. appreciate your reply.

[Lovely67]

Hi, I assume you haven’t started treatment and still in W&W. If so, what are your WBC count and do you have any lymph nodes? It is good to be in W&W.

[westcountrylad in reply to Lovely67]

yes I have started treatment, 2 nodes in juglar region of which the largest was 2 inches...i am old so don't do metric...lol