Work continued on this technology, and the first human trial was done in 2017. It was for rabies, whose currently approved vaccine is reportedly extremely painful and expensive. It contains egg, which is a major allergen. It also costs $1000-2000 which is a lot compared to Tdap, which is around $57. So a less expensive, efficacious vaccine was being looked at with this new tech.
Major publication on mRNA technology was done the following year in 2018: "mRNA vaccines-a new era in vaccinology". This paper discussed things like how lower costs and ease of manufacturing of mRNA vaccines compared favorably to older vaccine technology. How mRNA could stimulate a wide range of immune responses, involving B as well as T cells. It mentioned how, since the rapidity of initial SARS and MERS infections emerging just a few years previously, a newer tech that could be manufactured & distributed at much less expense was needed for these new rapidly emerging viruses. It stated "the development of more potent and versatile vaccine platforms is crucial" because the older tech took a lot longer to develop & manufacture.
It also mentioned the potential for mRNA tech to make anti-cancer vaccines.
So this tech has actually been in the pipeline at least a decade. The first human trials were 2 years before Covid-19 came along. I don't know why THIS type of information is not being widely publicized. Perhaps we should start writing our politicians and news media, requesting they disseminate the information.
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SofiaDeo
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Thanks SofiaDeo. We've frustratingly had a pandemic of misinformation with this viral pandemic, which some still believe doesn't exist. CLL is a rare cancer and our community has very many contact points with the best minds worldwide when it comes to recommending the best ways to stay safe with our CLL compromised immune systems. So I find it strange that some members consider that they can access more accurate CLL specific information from media and other sources who have negligible understanding of the best protective measures for us.
mRNA research actually goes back to 1961, with cancer trials in 2014. See neurodervish 's post which includes a nice timeline graphic. healthunlocked.com/cllsuppo... The use of mRNA medical technology for cancer shows a lot of promise. I'd say that it has well and truly proven itself as a very effective way of providing improved vaccination efficiency. Future mRNA COVID-19 vaccines may provide improved protection against SARS-COV-2 variants by using epitope targets on the virus that are less likely to change.
Ooo neurodervish, perhaps you could unlock that post of yours? IDK how I missed seeing it, must have been when I was sick a week or so. It's great information, I love that timeline, and IMO should be available to anyone on the 'net!
SofiaDeo, thanks for posting these facts unlocked. Please note that it's our policy not to unlock a post after someone has replied to it, since the person replying may not have felt comfortable replying to it if it was unlocked. People can join to read neurodervish 's post if they find your post.
Thank you Neil and SofiaDeo . I just unlocked that post as there were few replies and none of them appeared to contain personal info. This info feels like big news, so I am very happy it's being discussed more.
It looks like in 2017 not only were they testing rabies vaccines, but also an influenza one as well as anti-cancer ones. So it was used in humans more than the single rabies one. It appears we are fortunate, in that this mRNA tech had been "worked with" enough by the time Covid-19 hit, that it was able to be adapted quickly. If we only had the traditional vaccine technology, I bet we wouldn't yet have a vaccine and many many more would be dead or disabled. I too am more confident, especially since this tech appears to stimulate T as well as B cells. So we seem to be getting a bit more protection than "just antibodies", if our immune systems can still make them! IMO those who are still able to make serum proteins like IVIG and albumin, who do not need IVIG therapy and don't have constant infections, will likely make some T cells.
One of the concerns early on by some was that it would be impossible to produce an effective mRNA vaccine. Now we are spoiled for choice and debating which is the best!
in fact the research goes back significantly longer , in truth approximately 10 years. The world of science has long known that a virus would be coming,
It's happened several times so in anticipation mRNAresearch is at least a decade old .
Spanish flu, Bubonic plague were scary and learning events.
There are people who devote their entire work tenure to viral prevention research,.
Thanks to them we have the vaccines and thank goodness for these people. It's reassuring to know isn't it!
In comparison, the research behind rituximab began in the early 1980s, two decades later, with venetoclax related research beginning in the late 1980's.
Bruton's Tyrosine Kinase was discovered in 1993. Research of its key role in the B-cell Receptor pathway led to the development of Ibrutinib and many other BTK inhibitors. Many of us owe our lives to these drugs and are very thankful that they weren't going to be considered as experimental until a few more decades had passed!!
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