Over-80s show similar antibody responses following single vaccination with either Pfizer or AstraZeneca vaccine – but cellular responses are

[zaax]

birmingham.ac.uk/news/lates...

[bennevisplace]

... enhanced after Astrazeneca vaccine.

I heard a snippet on the radio this morning. It's a mystery as to why in this study AZ stimulated a significantly stronger T cell response, compared with Pfizer. I'm mildly encouraged, having booked my second shot of AZ for next week.

The Lancet pre-print is here papers.ssrn.com/sol3/papers...

[zaax in reply to bennevisplace]

They use different way of getting the piece of the spike in to active the immune system

Pfizer is an mRNA vaccine - RNA vaccines use only pathogen’s genetic code

The Oxford-AstraZeneca team used a modified version of a chimpanzee adenovirus, known as ChAdOx1

It is being said the the use of adenovirus which is also used in the J&J may be causing the clotting problems

[bennevisplace in reply to zaax]

Sure, I know there's a theory that one factor in the unusual blood-clot cases is the adenoviral DNA (there must be at least one rare cofactor or combination). But I'm not aware of any theory linking adenoviral DNA to enhanced T cell response - are you?

[lankisterguy Volunteer]

Hi zaax,-

I could not get your link to work, and after several tries this one did work for me here in the USA.

birmingham.ac.uk/news/lates...

-

Len