In This Week’s Alert:
CLL Society's 2019 ASH interview with Dr. Brian Koffman in which Dr. Neil Kay reinforces the idea that the course of CLL is influenced not only by the tumor but also by the “micro-environment” in which it lives inside the bone marrow. Investigations into understanding this micro-environment may ultimately lead us to better control of the disease.
Hope this is helpful!
I'd never heard of TNF before.
Real interesting if a way could be found to block the excess production.
Anti TNFs used a lot as a treatment for arthritis, been around a long time. Another great example of a repurposed drug.
That's even better news then. Could a trial start then to see if it helps those in W&W control symptoms?
I see TNF have lots of nasty side effects, BUT if you are just regulating down to a healthy level perhaps you can avoid those to some extent. Tricky to know though what's going on in the marrow.
Best wishes to all,
I would like to know about this also, good question Ernest2.
I think Mayo is looking into such research.
Mayo, always seem to be leading the way at researching the important peripheral stuff.
Sounds like from Dr. Kay's 2019 Lymphoma & Myeloma talk Dr. Fuhrman said, "a concern is triggering the risk of developing a richter's transformation." 23:20 youtu.be/yzTRCAcf2Ek