Use of selinexor with ibrutinib to overcome ibrutinib resistance

[SlowCLL]

New study involving the use of selinexor to overcome ibrutinib resistance is seen as a “breakthrough” by some people who are undoubtedly smarter than me. Interesting stuff, the plain English explanation is contained at “Breakthrough Increases Efficacy of B-Cell Lymphoid Malignancy Treatment”.

ajmc.com/newsroom/breakthro...

The far more complicated study itself is at “Resistance to BTK inhibition by ibrutinib can be overcome by preventing FOXO3a nuclear export and PI3K/AKT activation in B-cell lymphoid malignancies”.

researchgate.net/publicatio...

I would like to think of this as a Christmas present for those of us who have encountered Ibrutinib resistance.

Merry Christmas,

Owen

[lankisterguy Volunteer]

Hi SlowCLL,

Thanks for posting those two links. Interesting reading for those of us that have developed resistance.

I'm actually resistant to Zydelig/Idelalisib and intolerant of side effects from Imbruvica/Ibrutinib, so I look for information like those papers.

Len