Murano trial

[tomster]

Does anybody know something about Murano-trial?

[PlanetaryKim]

The MURANO trial ran from 2014-2017: clinicaltrials.gov/ct2/show....

It compared Venetoclax+rituximab (VR) to Bendamustine+rituximab (BR) in relapsed/refractory CLL patients and concluded that the VR was superior to the BR . Article here: bloodjournal.org/content/13...

As a result, some locations are now offering the VR combo as second line. Here in BC where I live, VR (as per the MURANO protocol) is what I will be offered if the ibrutinib ceases to work. I would get compassionate access to the Venetoclax because it has not been officially approved or funded or something in BC yet.

[tomster in reply to PlanetaryKim]

Thanks Kim