Kappa & Lambda

[PSP52]

Hi

Can anyone explain the kappa & lambda designation? I am predominately Kappa but really don't know what that means.

[cllady01 Former Volunteer]

This isn't light reading, but not too wonky to get the gist of either. I hope it helps you see the significance for diagnostics.

cytometry.org/web/modules/M...

[PSP52 in reply to cllady01]

Thank you !

[Cllcanada Top Poster CURE Hero in reply to cllady01]

I thought it was the fraternity and sorority that NOBODY wants to join!

🙄

~chris

[cllady01 Former Volunteer in reply to Cllcanada]

But, we only know that after the fact of being inducted!

[sweener in reply to cllady01]

Thanks for posting this. It isn't too "wonky" for sure. We have always said this is Greek to me. It is interesting about each lab having different protocols. Unlike the CBC, flow cytometry is an interpreted result, from a pathologist, but also depends on techniques in the lab to present a consistent sample....interesting for sure.

[DriedSeaweed]

Hm, unfortunately I am struggling to wrap my head around this. My Free Kappa/Free Lambda ratio is 2.38 (Free Kappa Light Chain is 2.09 mg/dL and Free Lambda Light Chains 0.88 mg/dL). This is higher than the normal range it looks like. I found a Dr. Susan Leclaire video where she relates it to MM. But what does it mean with regard to CLL?

[Cllcanada Top Poster CURE Hero in reply to DriedSeaweed]

Don't worry about the minutia...

Its not a prognostic indicator in either the CLL-IPI or iwCLL that I'm aware of...

This goes into more detail ...

ncbi.nlm.nih.gov/pmc/articl...

bloodjournal.org/content/bl...

[DriedSeaweed in reply to Cllcanada]

Okay thanks. Is this something that bounces around a lot?

[Cllcanada Top Poster CURE Hero in reply to DriedSeaweed]

No you are one or the other... as far as I know

[DriedSeaweed in reply to Cllcanada]

I think I read they do not filter out through your kidneys so I suppose it sticks around in the blood.