A question re: an Ibrutinib risk factor

[Yuck]

Does risk associated with ventricular

tachycardia increase the longer one takes Ibrutinib?

Thanks!

[AussieNeil Administrator]

I think this article from ASH2015 answers your question:

newevidence.com/oncology/at...

And here's a paper from 2014 that hypothesizes why Ibrutinib increases the risk of atrial fibrillation:

Ibrutinib increases the risk of atrial fibrillation, potentially through inhibition of cardiac PI3K-Akt signaling

bloodjournal.org/content/12...

Neil

[Berrytog in reply to AussieNeil]

Thank you Neil, as ever a font of useful information.

After seven years on on IB AF has raised it's head following my 2nd Hip Op in May, although there were signs in the first years but nothing for 5 years. Stopping then starting may have triggered it, a must for surgery. Or, the change in my Blood Pressure drugs following surgery my be the reason. The usual tests have not thrown up any cardiac malfuction so as a precaution against stroke or heart attack I am taking 30mg of Edoxaban daily to thin the blood. I do not like unknowns and might try going back on my old BP regime rather than accept the 'don't know' answer!!

[livinglifewell]

I've been on ibrutinib for 5 years and have noticed that my abnormal heart rhythms are happening more frequently and lasting a little longer. I don't know if it is A-fib or V-tach except that I don't experience dizziness or any change in a level of consciousness. Only once was my heart rate actually caught on the BP machine at 130 but no EKG was ordered. Cancer clinics tend not to chase after our ailments that can be kicked down the road or attributed to some other ailment.

[bhayes84 in reply to livinglifewell]

Alivecor has a $100 device (available on Amazon) called Kardia that lets you take your own EKG using your phone and it can tell you if you have Afib. You could email any unusual EKG to your doctor to convince him/her of what's happening.

[Cllcanada Top Poster CURE Hero in reply to bhayes84]

You can get a Holter monitor and a cardiologist, for practically the same price...

[bhayes84 in reply to Cllcanada]

True, although Kardia lets you check it at home and get immediate results. I actually bought it to be able to check for elevated ST segment that could indicate a heart attack. I don't know how accurate it's Afib detection is.

[livinglifewell in reply to Cllcanada]

I had a Holter Monitor once, it pretty much sucked. However, it did pick up an incredibly large amount of PVCs (bigeminy) that was directly attributed to my other cancer, carcinoid, and was several years prior to taking the ibrutinib or failing bendamustine. Once I had the surgery to remove the tumors the bigeminy resolved. I'll ask my hematologist about the Kardia.