Bone barrow biopsy in cml

[sumit-dubey]

I am describing my fathers report below can anyone tell me what that mean

Microscopic Description:

Bone marrow biopsy :

Hypercellular bone marrow showing myeloid preponderance with adequate maturation.

Megakaryocytes are increased and shows dyspoietic changes included micromegakaryocytes.

Erythroid are relatively reduced.

No fibrosis seen.

No increase in blasts seen.

[AussieNeil Partner Administrator]

This community supports those with CLL, not CML, so we don't have personal experience of CML bone marrow biopsy results. That said, Jm954 may be prepared to comment.

Neil

[Jm954 Administrator]

Thanks AussieNeil

Hi, is that everything that it says? Is there a M:E ratio quoted or any comment about lymphoid cells?

In your previous post it appeared that both the myeloid and lymphoid cells were increased in the blood.

You father may have CML, the report would be similar to this. The abnormal and small megakaryocytes (dyspoietic) are not typical of CML but, more commonly, myelodysplasia. However, the report as you've posted it makes no mention of any other cell lines appearing dysplastic.

To confirm CML, a genetic test called BCR-ABL testing should be done and can be carried out on blood.

From this report I don't think you have the answers yet but some things have been excluded.