Duvelisib or not?: Duvelisib is the new upcoming... - CLL Support

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Duvelisib or not?

lamboman
lamboman

Duvelisib is the new upcoming PI3K inhibitor and I was wondering if any of my CLL fellows had experience with the drug. I am on the CAPTIVATE trial combining Ibrutinib and Venetoclax and it seems to me that adding something like Duvelisib would go after another pathway to neutralize whatever could be left of the CLL. I am trying to assess if the drug will actually be effective as a mono therapy or only in combination.

3 Replies
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Cllcanada
CllcanadaTop Poster CURE Hero

Dr. Matthew Davids has a duvelisib and venetoclax clinic trial in the wings, should open later this year. It is a safety and dosing trial primarily.

clinicaltrials.gov/ct2/show...

I was on idelalisib and rituxan, same pathway... I did well, friends of mine had a lot of problems... however.

~chris

lamboman
lamboman
in reply to Cllcanada

Thank you for the reply. I wonder if/how these 2 drugs are different.

Cllcanada
CllcanadaTop Poster CURE Hero
in reply to lamboman

Zydelig (idelalisib) is a delta isoform, duvelisib is a delta/gamma isoform.

Duvelisib appears to be better targeted, with fewer side effects.

en.m.wikipedia.org/wiki/Duv...

Umbralisib, will be along at some point as well...

en.m.wikipedia.org/wiki/Umb...

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