Not MRD- yet

[Yvbb]

Although a full remission due to the excellent synergy of Ibrutinib (9 periods) and Venetoclax (6 periods) there is still a level of approx 10 percent of cll disease in my pb. Ofcourse I hoped to be one of the succesful cohort Dr. William Wierda presented on Asco 2018; more than 70 percent seems to get to this impressive result within a few months. I will have another evaluation after period 12 and 15. So MRD - could be in reach for me too. I had to stop taking Vtclx for a week and reduce the dose for another week due to neutrophelia in period 9. Fingers crossed🤞🏻.

Yvonne

[fell]

You’ll get there, Yvonne! 🙏

I’m on the same trial (finished my ramp up to 400 mg of V on Wednesday )

Best,

Fell

[Emcee1 in reply to fell]

Fell

I am finishing week one of Venetaclax any side effects at full throttle?

Mike...

[fell in reply to Emcee1]

Hi Mike, I replied earlier, but it looks like it didn’t go through. The 400 mg is a little bit challenging. I am experiencing nausea and a lot of fatigue. I have decided to change the timing from morning to night, so I am slowly moving up the time when I take both medications until I get to about 9:30 PM for Ibrutinib and then 10:30 pm for venetoclax. I think I’m in the minority, most people tolerate it well.

[Emcee1 in reply to fell]

Thanks. I will post my results as well for those that follow. Again, thanks for the heads up!

[Mystic75]

Hang in there Yvonne! Lot's of reasons to be very positive!!!

Fingers crossed for you!

D.

[pkpayne]

Yvbb it looks like you are headed that way - to MRD! Great news! Dr. Wierda is also my doctor and I hope I make to MRD as well although I'm not there yet. Just had my 4th BMB but don't know the results of it yet. My fingers are crossed - for both of us! Keep on keeping on.

Paula

[fell in reply to pkpayne]

Wishing you the best, Paula! 🙏

[pkpayne in reply to fell]

And you too fell!

Paula

[yoniboi]

Good luck guys. You're leading the way for the rest of us there. Great to hear how you're getting on!

[BettinaB]

Keeping my fingers crossed for you Yvbb and for everyone else too, of course. You are courageous, altruistic and generally to be admired!

[Yvbb in reply to BettinaB]

Thank you so much for the support. I read this somewhere: it is not all about the medicine, it is the luck you can have and the support that can make the difference.❤️

[Emcee1]

All the best! Keep posting please as I am a few months behind you and I am sure there are others as well! We like good news!

Sending prayers!

Mike

[closh]

Hi Yvonne

I was one of the first 14 on the trial and wasn't MRD- at your stage either. After the 15 month evaluation though, I reached MRD- "undetectable" as did 11 others (12 from 14). It takes a little while to keep hammering on the toughest of those nasty little CLL cells.

Graham